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Discovery of 5-Phenyl-N-(pyridin-2-ylmethyl)-2-(pyrimidin-5-yl)quinazolin-4-amine as a Potent I Kur Inhibitor.
Finlay HJ, Johnson JA, Lloyd JL, Jiang J, Neels J, Gunaga P, Banerjee A, Dhondi N, Chimalakonda A, Mandlekar S, Conder ML, Sale H, Xing D, Levesque P, Wexler RR. Finlay HJ, et al. Among authors: lloyd jl. ACS Med Chem Lett. 2016 Jun 9;7(9):831-4. doi: 10.1021/acsmedchemlett.6b00117. eCollection 2016 Sep 8. ACS Med Chem Lett. 2016. PMID: 27660686 Free PMC article.
Tetrahydronaphthalene-derived amino alcohols and amino ketones as potent and selective inhibitors of the delayed rectifier potassium current IKs.
Ahmad S, Doweyko L, Ashfaq A, Ferrara FN, Bisaha SN, Schmidt JB, DiMarco J, Conder ML, Jenkins-West T, Normandin DE, Russell AD, Smith MA, Levesque PC, Lodge NJ, Lloyd J, Stein PD, Atwal KS. Ahmad S, et al. Bioorg Med Chem Lett. 2004 Jan 5;14(1):99-102. doi: 10.1016/j.bmcl.2003.10.003. Bioorg Med Chem Lett. 2004. PMID: 14684307
Benzopyran sulfonamides as KV1.5 potassium channel blockers.
Lloyd J, Atwal KS, Finlay HJ, Nyman M, Huynh T, Bhandaru R, Kover A, Schmidt J, Vaccaro W, Conder ML, Jenkins-West T, Levesque P. Lloyd J, et al. Bioorg Med Chem Lett. 2007 Jun 15;17(12):3271-5. doi: 10.1016/j.bmcl.2007.04.020. Epub 2007 Apr 10. Bioorg Med Chem Lett. 2007. PMID: 17462888
Pyrano-[2,3b]-pyridines as potassium channel antagonists.
Finlay HJ, Lloyd J, Nyman M, Conder ML, West T, Levesque P, Atwal K. Finlay HJ, et al. Bioorg Med Chem Lett. 2008 Apr 15;18(8):2714-8. doi: 10.1016/j.bmcl.2008.03.026. Epub 2008 Mar 14. Bioorg Med Chem Lett. 2008. PMID: 18374568
Dihydropyrazolopyrimidine inhibitors of K(V)1.5 (I(Kur)).
Vaccaro W, Huynh T, Lloyd J, Atwal K, Finlay HJ, Levesque P, Conder ML, Jenkins-West T, Shi H, Sun L. Vaccaro W, et al. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6381-5. doi: 10.1016/j.bmcl.2008.10.099. Epub 2008 Oct 25. Bioorg Med Chem Lett. 2008. PMID: 19004630
32 results