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1,189 results

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Artemin-GFRα3 interactions partially contribute to acute inflammatory hypersensitivity.
Thornton P, Hatcher JP, Robinson I, Sargent B, Franzén B, Martino G, Kitching L, Glover CP, Anderson D, Forsmo-Bruce H, Low CP, Cusdin F, Dosanjh B, Williams W, Steffen AC, Thompson S, Eklund M, Lloyd C, Chessell I, Hughes J. Thornton P, et al. Among authors: lloyd c. Neurosci Lett. 2013 Jun 17;545:23-8. doi: 10.1016/j.neulet.2013.04.007. Epub 2013 Apr 19. Neurosci Lett. 2013. PMID: 23603259
Preclinical development of a high affinity α-synuclein antibody, MEDI1341, that can enter the brain, sequester extracellular α-synuclein and attenuate α-synuclein spreading in vivo.
Schofield DJ, Irving L, Calo L, Bogstedt A, Rees G, Nuccitelli A, Narwal R, Petrone M, Roberts J, Brown L, Cusdin F, Dosanjh B, Lloyd C, Dobson C, Gurrell I, Fraser G, McFarlane M, Rockenstein E, Spencer B, Masliah E, Spillantini MG, Tan K, Billinton A, Vaughan T, Chessell I, Perkinton MS. Schofield DJ, et al. Among authors: lloyd c. Neurobiol Dis. 2019 Dec;132:104582. doi: 10.1016/j.nbd.2019.104582. Epub 2019 Aug 21. Neurobiol Dis. 2019. PMID: 31445162 Free article.
Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo.
Dobson CL, Devine PW, Phillips JJ, Higazi DR, Lloyd C, Popovic B, Arnold J, Buchanan A, Lewis A, Goodman J, van der Walle CF, Thornton P, Vinall L, Lowne D, Aagaard A, Olsson LL, Ridderstad Wollberg A, Welsh F, Karamanos TK, Pashley CL, Iadanza MG, Ranson NA, Ashcroft AE, Kippen AD, Vaughan TJ, Radford SE, Lowe DC. Dobson CL, et al. Among authors: lloyd c. Sci Rep. 2016 Dec 20;6:38644. doi: 10.1038/srep38644. Sci Rep. 2016. PMID: 27995962 Free PMC article.
MHC class I chain-related protein A and B (MICA and MICB) are predominantly expressed intracellularly in tumour and normal tissue.
Ghadially H, Brown L, Lloyd C, Lewis L, Lewis A, Dillon J, Sainson R, Jovanovic J, Tigue NJ, Bannister D, Bamber L, Valge-Archer V, Wilkinson RW. Ghadially H, et al. Among authors: lloyd c. Br J Cancer. 2017 Apr 25;116(9):1208-1217. doi: 10.1038/bjc.2017.79. Epub 2017 Mar 23. Br J Cancer. 2017. PMID: 28334733 Free PMC article.
An in vivo platform to select and evolve aggregation-resistant proteins.
Ebo JS, Saunders JC, Devine PWA, Gordon AM, Warwick AS, Schiffrin B, Chin SE, England E, Button JD, Lloyd C, Bond NJ, Ashcroft AE, Radford SE, Lowe DC, Brockwell DJ. Ebo JS, et al. Among authors: lloyd c. Nat Commun. 2020 Apr 14;11(1):1816. doi: 10.1038/s41467-020-15667-1. Nat Commun. 2020. PMID: 32286330 Free PMC article.
Preclinical Evaluation of MEDI0641, a Pyrrolobenzodiazepine-Conjugated Antibody-Drug Conjugate Targeting 5T4.
Harper J, Lloyd C, Dimasi N, Toader D, Marwood R, Lewis L, Bannister D, Jovanovic J, Fleming R, D'Hooge F, Mao S, Marrero AM, Korade M 3rd, Strout P, Xu L, Chen C, Wetzel L, Breen S, van Vlerken-Ysla L, Jalla S, Rebelatto M, Zhong H, Hurt EM, Hinrichs MJ, Huang K, Howard PW, Tice DA, Hollingsworth RE, Herbst R, Kamal A. Harper J, et al. Among authors: lloyd c. Mol Cancer Ther. 2017 Aug;16(8):1576-1587. doi: 10.1158/1535-7163.MCT-16-0825. Epub 2017 May 18. Mol Cancer Ther. 2017. PMID: 28522587
A novel IgE-neutralizing antibody for the treatment of severe uncontrolled asthma.
Cohen ES, Dobson CL, Käck H, Wang B, Sims DA, Lloyd CO, England E, Rees DG, Guo H, Karagiannis SN, O'Brien S, Persdotter S, Ekdahl H, Butler R, Keyes F, Oakley S, Carlsson M, Briend E, Wilkinson T, Anderson IK, Monk PD, von Wachenfeldt K, Eriksson PO, Gould HJ, Vaughan TJ, May RD. Cohen ES, et al. MAbs. 2014 May-Jun;6(3):756-64. doi: 10.4161/mabs.28394. Epub 2014 Feb 28. MAbs. 2014. PMID: 24583620 Free PMC article.
1,189 results