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The exposure of highly toxic aconitine does not significantly impact the activity and expression of cytochrome P450 3A in rats determined by a novel ultra performance liquid chromatography-tandem mass spectrometric method of a specific probe buspirone.
Zhu L, Yang X, Zhou J, Tang L, Xia B, Hu M, Zhou F, Liu Z. Zhu L, et al. Among authors: liu z. Food Chem Toxicol. 2013 Jan;51:396-403. doi: 10.1016/j.fct.2012.10.008. Epub 2012 Oct 22. Food Chem Toxicol. 2013. PMID: 23085095
Significantly decreased and more variable expression of major CYPs and UGTs in liver microsomes prepared from HBV-positive human hepatocellular carcinoma and matched pericarcinomatous tissues determined using an isotope label-free UPLC-MS/MS method.
Yan T, Gao S, Peng X, Shi J, Xie C, Li Q, Lu L, Wang Y, Zhou F, Liu Z, Hu M. Yan T, et al. Among authors: liu z. Pharm Res. 2015 Mar;32(3):1141-57. doi: 10.1007/s11095-014-1525-x. Epub 2014 Oct 8. Pharm Res. 2015. PMID: 25288013 Free PMC article.
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