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Cholesterol biosynthesis supports the growth of hepatocarcinoma lesions depleted of fatty acid synthase in mice and humans.
Che L, Chi W, Qiao Y, Zhang J, Song X, Liu Y, Li L, Jia J, Pilo MG, Wang J, Cigliano A, Ma Z, Kuang W, Tang Z, Zhang Z, Shui G, Ribback S, Dombrowski F, Evert M, Pascale RM, Cossu C, Pes GM, Osborne TF, Calvisi DF, Chen X, Chen L. Che L, et al. Among authors: liu y. Gut. 2020 Jan;69(1):177-186. doi: 10.1136/gutjnl-2018-317581. Epub 2019 Apr 6. Gut. 2020. PMID: 30954949 Free PMC article.
Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicity.
Cheng L, Ge M, Lan Z, Ma Z, Chi W, Kuang W, Sun K, Zhao X, Liu Y, Feng Y, Huang Y, Luo M, Li L, Zhang B, Hu X, Xu L, Liu X, Huo Y, Deng H, Yang J, Xi Q, Zhang Y, Siegenthaler JA, Chen L. Cheng L, et al. Among authors: liu y, liu x. Arch Toxicol. 2018 Jan;92(1):469-485. doi: 10.1007/s00204-017-2048-0. Epub 2017 Sep 4. Arch Toxicol. 2018. PMID: 28871336 Free PMC article.
Organic cation transporter 3 (Oct3) is a distinct catecholamines clearance route in adipocytes mediating the beiging of white adipose tissue.
Song W, Luo Q, Zhang Y, Zhou L, Liu Y, Ma Z, Guo J, Huang Y, Cheng L, Meng Z, Li Z, Zhang B, Li S, Yee SW, Fan H, Li P, Giacomini KM, Chen L. Song W, et al. Among authors: liu y. PLoS Biol. 2019 Jan 17;17(1):e2006571. doi: 10.1371/journal.pbio.2006571. eCollection 2019 Jan. PLoS Biol. 2019. PMID: 30653498 Free PMC article.
Ablation of Proton/Glucose Exporter SLC45A2 Enhances Melanosomal Glycolysis to Inhibit Melanin Biosynthesis and Promote Melanoma Metastasis.
Liu Y, Chi W, Tao L, Wang G, Deepak RNVK, Sheng L, Chen T, Feng Y, Cao X, Cheng L, Zhao X, Liu X, Deng H, Fan H, Jiang P, Chen L. Liu Y, et al. Among authors: liu x. J Invest Dermatol. 2022 Oct;142(10):2744-2755.e9. doi: 10.1016/j.jid.2022.04.008. Epub 2022 Apr 23. J Invest Dermatol. 2022. PMID: 35469906 Free article.
mTOR-dependent upregulation of xCT blocks melanin synthesis and promotes tumorigenesis.
Li C, Chen H, Lan Z, He S, Chen R, Wang F, Liu Z, Li K, Cheng L, Liu Y, Sun K, Wan X, Chen X, Peng H, Li L, Zhang Y, Jing Y, Huang M, Wang Y, Wang Y, Jiang J, Zha X, Chen L, Zhang H. Li C, et al. Among authors: liu z, liu y. Cell Death Differ. 2019 Oct;26(10):2015-2028. doi: 10.1038/s41418-019-0274-0. Epub 2019 Feb 13. Cell Death Differ. 2019. PMID: 30760873 Free PMC article.
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