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Selective decrease of donor-reactive Tregs after liver transplantation limits Treg therapy for promoting allograft tolerance in humans.
Tang Q, Leung J, Peng Y, Sanchez-Fueyo A, Lozano JJ, Lam A, Lee K, Greenland JR, Hellerstein M, Fitch M, Li KW, Esensten JH, Putnam AL, Lares A, Nguyen V, Liu W, Bridges ND, Odim J, Demetris AJ, Levitsky J, Taner T, Feng S. Tang Q, et al. Among authors: liu w. Sci Transl Med. 2022 Nov 2;14(669):eabo2628. doi: 10.1126/scitranslmed.abo2628. Epub 2022 Nov 2. Sci Transl Med. 2022. PMID: 36322627 Free PMC article. Clinical Trial.
Type 1 diabetes immunotherapy using polyclonal regulatory T cells.
Bluestone JA, Buckner JH, Fitch M, Gitelman SE, Gupta S, Hellerstein MK, Herold KC, Lares A, Lee MR, Li K, Liu W, Long SA, Masiello LM, Nguyen V, Putnam AL, Rieck M, Sayre PH, Tang Q. Bluestone JA, et al. Among authors: liu w. Sci Transl Med. 2015 Nov 25;7(315):315ra189. doi: 10.1126/scitranslmed.aad4134. Sci Transl Med. 2015. PMID: 26606968 Free PMC article. Clinical Trial.
The effect of low-dose IL-2 and Treg adoptive cell therapy in patients with type 1 diabetes.
Dong S, Hiam-Galvez KJ, Mowery CT, Herold KC, Gitelman SE, Esensten JH, Liu W, Lares AP, Leinbach AS, Lee M, Nguyen V, Tamaki SJ, Tamaki W, Tamaki CM, Mehdizadeh M, Putnam AL, Spitzer MH, Ye CJ, Tang Q, Bluestone JA. Dong S, et al. Among authors: liu w. JCI Insight. 2021 Sep 22;6(18):e147474. doi: 10.1172/jci.insight.147474. JCI Insight. 2021. PMID: 34324441 Free PMC article. Clinical Trial.
Polyclonal Regulatory T Cell Manufacturing Under cGMP: A Decade of Experience.
Balcerek J, Shy BR, Putnam AL, Masiello LM, Lares A, Dekovic F, Acevedo L, Lee MR, Nguyen V, Liu W, Paruthiyil S, Xu J, Leinbach AS, Bluestone JA, Tang Q, Esensten JH. Balcerek J, et al. Among authors: liu w. Front Immunol. 2021 Nov 18;12:744763. doi: 10.3389/fimmu.2021.744763. eCollection 2021. Front Immunol. 2021. PMID: 34867967 Free PMC article.
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