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A bacterial extracellular vesicle-based intranasal vaccine against SARS-CoV-2 protects against disease and elicits neutralizing antibodies to wild-type and Delta variants.
Jiang L, Driedonks TAP, Jong WSP, Dhakal S, Bart van den Berg van Saparoea H, Sitaras I, Zhou R, Caputo C, Littlefield K, Lowman M, Chen M, Lima G, Gololobova O, Smith B, Mahairaki V, Riley Richardson M, Mulka KR, Lane AP, Klein SL, Pekosz A, Brayton C, Mankowski JL, Luirink J, Villano JS, Witwer KW. Jiang L, et al. Among authors: littlefield k. J Extracell Vesicles. 2022 Mar;11(3):e12192. doi: 10.1002/jev2.12192. J Extracell Vesicles. 2022. PMID: 35289114 Free PMC article.
Progression and Resolution of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Golden Syrian Hamsters.
Mulka KR, Beck SE, Solis CV, Johanson AL, Queen SE, McCarron ME, Richardson MR, Zhou R, Marinho P, Jedlicka A, Guerrero-Martin S, Shirk EN, Braxton AM, Brockhurst J, Creisher PS, Dhakal S, Brayton CF, Veenhuis RT, Metcalf Pate KA, Karakousis PC, Zahnow CA, Klein SL, Jain SK, Tarwater PM, Pekosz AS, Villano JS, Mankowski JL; Johns Hopkins COVID-19 Hamster Study Group. Mulka KR, et al. Am J Pathol. 2022 Feb;192(2):195-207. doi: 10.1016/j.ajpath.2021.10.009. Epub 2021 Nov 10. Am J Pathol. 2022. PMID: 34767812 Free PMC article.
Durable SARS-CoV-2 B cell immunity after mild or severe disease.
Ogega CO, Skinner NE, Blair PW, Park HS, Littlefield K, Ganesan A, Dhakal S, Ladiwala P, Antar AA, Ray SC, Betenbaugh MJ, Pekosz A, Klein SL, Manabe YC, Cox AL, Bailey JR. Ogega CO, et al. Among authors: littlefield k. J Clin Invest. 2021 Apr 1;131(7):e145516. doi: 10.1172/JCI145516. J Clin Invest. 2021. PMID: 33571162 Free PMC article.
Sex Differences in Lung Imaging and SARS-CoV-2 Antibody Responses in a COVID-19 Golden Syrian Hamster Model.
Dhakal S, Ruiz-Bedoya CA, Zhou R, Creisher PS, Villano JS, Littlefield K, Ruelas Castillo J, Marinho P, Jedlicka AE, Ordonez AA, Bahr M, Majewska N, Betenbaugh MJ, Flavahan K, Mueller ARL, Looney MM, Quijada D, Mota F, Beck SE, Brockhurst J, Braxton AM, Castell N, Stover M, D'Alessio FR, Metcalf Pate KA, Karakousis PC, Mankowski JL, Pekosz A, Jain SK, Klein SL; Johns Hopkins COVID-19 Hamster Study Group. Dhakal S, et al. Among authors: littlefield k. mBio. 2021 Aug 31;12(4):e0097421. doi: 10.1128/mBio.00974-21. Epub 2021 Jul 13. mBio. 2021. PMID: 34253053 Free PMC article.
Pharmacokinetics of high-titer anti-SARS-CoV-2 human convalescent plasma in high-risk children.
Gordon O, Brosnan MK, Yoon S, Jung D, Littlefield K, Ganesan A, Caputo CA, Li M, Morgenlander WR, Henson SN, Ordonez AA, De Jesus P, Tucker EW, Peart Akindele N, Ma Z, Wilson J, Ruiz-Bedoya CA, Younger MEM, Bloch EM, Shoham S, Sullivan D, Tobian AA, Cooke KR, Larman B, Gobburu JV, Casadevall A, Pekosz A, Lederman HM, Klein SL, Jain SK. Gordon O, et al. Among authors: littlefield k. JCI Insight. 2022 Jan 25;7(2):e151518. doi: 10.1172/jci.insight.151518. JCI Insight. 2022. PMID: 34855624 Free PMC article. Clinical Trial.
Greater Breadth of Vaccine-Induced Immunity in Females than Males Is Mediated by Increased Antibody Diversity in Germinal Center B Cells.
Ursin RL, Dhakal S, Liu H, Jayaraman S, Park HS, Powell HR, Sherer ML, Littlefield KE, Fink AL, Ma Z, Mueller AL, Chen AP, Seddu K, Woldetsadik YA, Gearhart PJ, Larman HB, Maul RW, Pekosz A, Klein SL. Ursin RL, et al. Among authors: littlefield ke. mBio. 2022 Aug 30;13(4):e0183922. doi: 10.1128/mbio.01839-22. Epub 2022 Jul 20. mBio. 2022. PMID: 35856618 Free PMC article.
Durable SARS-CoV-2 B cell immunity after mild or severe disease.
Ogega CO, Skinner NE, Blair PW, Park HS, Littlefield K, Ganesan A, Ladiwala P, Antar AA, Ray SC, Betenbaugh MJ, Pekosz A, Klein SL, Manabe YC, Cox AL, Bailey JR. Ogega CO, et al. Among authors: littlefield k. medRxiv [Preprint]. 2020 Oct 30:2020.10.28.20220996. doi: 10.1101/2020.10.28.20220996. medRxiv. 2020. PMID: 33140070 Free PMC article. Updated. Preprint.
Markers of Polyfunctional SARS-CoV-2 Antibodies in Convalescent Plasma.
Natarajan H, Crowley AR, Butler SE, Xu S, Weiner JA, Bloch EM, Littlefield K, Wieland-Alter W, Connor RI, Wright PF, Benner SE, Bonny TS, Laeyendecker O, Sullivan D, Shoham S, Quinn TC, Larman HB, Casadevall A, Pekosz A, Redd AD, Tobian AAR, Ackerman ME. Natarajan H, et al. Among authors: littlefield k. mBio. 2021 Apr 20;12(2):e00765-21. doi: 10.1128/mBio.00765-21. mBio. 2021. PMID: 33879585 Free PMC article.
Sex, age, and hospitalization drive antibody responses in a COVID-19 convalescent plasma donor population.
Klein SL, Pekosz A, Park HS, Ursin RL, Shapiro JR, Benner SE, Littlefield K, Kumar S, Naik HM, Betenbaugh MJ, Shrestha R, Wu AA, Hughes RM, Burgess I, Caturegli P, Laeyendecker O, Quinn TC, Sullivan D, Shoham S, Redd AD, Bloch EM, Casadevall A, Tobian AA. Klein SL, et al. Among authors: littlefield k. J Clin Invest. 2020 Nov 2;130(11):6141-6150. doi: 10.1172/JCI142004. J Clin Invest. 2020. PMID: 32764200 Free PMC article.
SARS-CoV-2-specific CD8+ T cell responses in convalescent COVID-19 individuals.
Kared H, Redd AD, Bloch EM, Bonny TS, Sumatoh H, Kairi F, Carbajo D, Abel B, Newell EW, Bettinotti MP, Benner SE, Patel EU, Littlefield K, Laeyendecker O, Shoham S, Sullivan D, Casadevall A, Pekosz A, Nardin A, Fehlings M, Tobian AA, Quinn TC. Kared H, et al. Among authors: littlefield k. J Clin Invest. 2021 Mar 1;131(5):e145476. doi: 10.1172/JCI145476. J Clin Invest. 2021. PMID: 33427749 Free PMC article. Clinical Trial.
62 results