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Development of Large-Scale Downstream Processing for Lentiviral Vectors.
Mol Ther Methods Clin Dev. 2020 Mar 30;17:717-730. doi: 10.1016/j.omtm.2020.03.025. eCollection 2020 Jun 12.
Mol Ther Methods Clin Dev. 2020.
PMID: 32346549
Free PMC article.
Optimization of lentiviral vector production for scale-up in fixed-bed bioreactor.
Valkama AJ, Leinonen HM, Lipponen EM, Turkki V, Malinen J, Heikura T, Ylä-Herttuala S, Lesch HP.
Valkama AJ, et al. Among authors: lipponen em.
Gene Ther. 2018 Jan;25(1):39-46. doi: 10.1038/gt.2017.91. Epub 2017 Oct 5.
Gene Ther. 2018.
PMID: 29345252
Free PMC article.
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Preclinical Proof-of-Concept, Analytical Development, and Commercial Scale Production of Lentiviral Vector in Adherent Cells.
Leinonen HM, Lipponen EM, Valkama AJ, Hynynen H, Oruetxebarria I, Turkki V, Olsson V, Kurkipuro J, Samaranayake H, Määttä AM, Parker NR, Ylä-Herttuala S, Lesch HP.
Leinonen HM, et al. Among authors: lipponen em.
Mol Ther Methods Clin Dev. 2019 Aug 29;15:63-71. doi: 10.1016/j.omtm.2019.08.006. eCollection 2019 Dec 13.
Mol Ther Methods Clin Dev. 2019.
PMID: 31649956
Free PMC article.
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Benchmarking of Scale-X Bioreactor System in Lentiviral and Adenoviral Vector Production.
Leinonen HM, Lepola S, Lipponen EM, Heikura T, Koponen T, Parker N, Ylä-Herttuala S, Lesch HP.
Leinonen HM, et al. Among authors: lipponen em.
Hum Gene Ther. 2020 Mar;31(5-6):376-384. doi: 10.1089/hum.2019.247.
Hum Gene Ther. 2020.
PMID: 32075423
Free PMC article.
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Process Development of Adenoviral Vector Production in Fixed Bed Bioreactor: From Bench to Commercial Scale.
Lesch HP, Heikkilä KM, Lipponen EM, Valonen P, Müller A, Räsänen E, Tuunanen T, Hassinen MM, Parker N, Karhinen M, Shaw R, Ylä-Herttuala S.
Lesch HP, et al. Among authors: lipponen em.
Hum Gene Ther. 2015 Aug;26(8):560-71. doi: 10.1089/hum.2015.081.
Hum Gene Ther. 2015.
PMID: 26176404
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Corrigendum: Optimized riboswitch-regulated AAV vector for VEGF-B gene therapy.
Eriksson RAE, Nieminen T, Galibert L, Peltola SK, Tikkanen P, Käyhty P, Leinonen HM, Oruetxebarria I, Lepola S, Valkama AJ, Lipponen EM, Lesch HP, Ylä-Herttuala S, Airenne KJ.
Eriksson RAE, et al. Among authors: lipponen em.
Front Med (Lausanne). 2023 Mar 3;10:1143748. doi: 10.3389/fmed.2023.1143748. eCollection 2023.
Front Med (Lausanne). 2023.
PMID: 36936246
Free PMC article.
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