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TIC10/ONC201: a bend in the road to clinical development.
Greer YE, Lipkowitz S. Greer YE, et al. Among authors: lipkowitz s. Oncoscience. 2015 Feb 20;2(2):75-6. doi: 10.18632/oncoscience.133. eCollection 2015. Oncoscience. 2015. PMID: 25859547 Free PMC article. No abstract available.
The TRAIL receptor agonist drozitumab targets basal B triple-negative breast cancer cells that express vimentin and Axl.
Dine JL, O'Sullivan CC, Voeller D, Greer YE, Chavez KJ, Conway CM, Sinclair S, Stone B, Amiri-Kordestani L, Merchant AS, Hewitt SM, Steinberg SM, Swain SM, Lipkowitz S. Dine JL, et al. Among authors: lipkowitz s. Breast Cancer Res Treat. 2016 Jan;155(2):235-51. doi: 10.1007/s10549-015-3673-z. Epub 2016 Jan 12. Breast Cancer Res Treat. 2016. PMID: 26759246 Free PMC article.
ONC201 kills breast cancer cells in vitro by targeting mitochondria.
Greer YE, Porat-Shliom N, Nagashima K, Stuelten C, Crooks D, Koparde VN, Gilbert SF, Islam C, Ubaldini A, Ji Y, Gattinoni L, Soheilian F, Wang X, Hafner M, Shetty J, Tran B, Jailwala P, Cam M, Lang M, Voeller D, Reinhold WC, Rajapakse V, Pommier Y, Weigert R, Linehan WM, Lipkowitz S. Greer YE, et al. Among authors: lipkowitz s. Oncotarget. 2018 Apr 6;9(26):18454-18479. doi: 10.18632/oncotarget.24862. eCollection 2018 Apr 6. Oncotarget. 2018. PMID: 29719618 Free PMC article.
MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 2 agonist, causes regression of orthotopic tumors and inhibits outgrowth of metastatic triple-negative breast cancer.
Greer YE, Gilbert SF, Gril B, Narwal R, Peacock Brooks DL, Tice DA, Steeg PS, Lipkowitz S. Greer YE, et al. Among authors: lipkowitz s. Breast Cancer Res. 2019 Feb 18;21(1):27. doi: 10.1186/s13058-019-1116-1. Breast Cancer Res. 2019. PMID: 30777098 Free PMC article.
Cbl interacts with multiple E2s in vitro and in cells.
Liyasova MS, Ma K, Voeller D, Ryan PE, Chen J, Klevit RE, Lipkowitz S. Liyasova MS, et al. Among authors: lipkowitz s. PLoS One. 2019 May 23;14(5):e0216967. doi: 10.1371/journal.pone.0216967. eCollection 2019. PLoS One. 2019. PMID: 31120930 Free PMC article.
Sinularamides A-G, Terpenoid-Derived Spermidine and Spermine Conjugates with Casitas B-Lineage Lymphoma Proto-Oncogene B (Cbl-b) Inhibitory Activities from a Sinularia sp. Soft Coral.
Jiang W, Wang D, Wilson BAP, Voeller D, Bokesch HR, Smith EA, Lipkowitz S, O'Keefe BR, Gustafson KR. Jiang W, et al. Among authors: lipkowitz s. J Nat Prod. 2021 Jun 25;84(6):1831-1837. doi: 10.1021/acs.jnatprod.1c00367. Epub 2021 May 26. J Nat Prod. 2021. PMID: 34038132 Free PMC article.
132 results