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The herpesvirus UL49.5 protein hijacks a cellular C-degron pathway to drive TAP transporter degradation.
Wąchalska M, Riepe C, Ślusarz MJ, Graul M, Borowski LS, Qiao W, Foltyńska M, Carette JE, Bieńkowska-Szewczyk K, Szczesny RJ, Kopito RR, Lipińska AD. Wąchalska M, et al. Among authors: lipinska ad. Proc Natl Acad Sci U S A. 2024 Mar 12;121(11):e2309841121. doi: 10.1073/pnas.2309841121. Epub 2024 Mar 5. Proc Natl Acad Sci U S A. 2024. PMID: 38442151
The N-terminal Proline Hinge Motif Controls the Structure of Bovine Herpesvirus 1-encoded Inhibitor of the Transporter Associated with Antigen Processing Required for its Immunomodulatory Function.
Graul M, Karska N, Wąchalska M, Krupa P, Ślusarz MJ, Lubocki M, Bieńkowska-Szewczyk K, Rodziewicz-Motowidło S, Sieradzan AK, Lipińska AD. Graul M, et al. Among authors: lipinska ad. J Mol Biol. 2023 Mar 1;435(5):167964. doi: 10.1016/j.jmb.2023.167964. Epub 2023 Jan 13. J Mol Biol. 2023. PMID: 36646375 Free article.
Varicelloviruses avoid T cell recognition by UL49.5-mediated inactivation of the transporter associated with antigen processing.
Koppers-Lalic D, Reits EA, Ressing ME, Lipinska AD, Abele R, Koch J, Marcondes Rezende M, Admiraal P, van Leeuwen D, Bienkowska-Szewczyk K, Mettenleiter TC, Rijsewijk FA, Tampé R, Neefjes J, Wiertz EJ. Koppers-Lalic D, et al. Among authors: lipinska ad. Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):5144-9. doi: 10.1073/pnas.0501463102. Epub 2005 Mar 25. Proc Natl Acad Sci U S A. 2005. PMID: 15793001 Free PMC article.
Structure determination of UL49.5 transmembrane protein from bovine herpesvirus 1 by NMR spectroscopy and molecular dynamics.
Karska N, Graul M, Sikorska E, Zhukov I, Ślusarz MJ, Kasprzykowski F, Lipińska AD, Rodziewicz-Motowidło S. Karska N, et al. Among authors: lipinska ad. Biochim Biophys Acta Biomembr. 2019 May 1;1861(5):926-938. doi: 10.1016/j.bbamem.2019.02.005. Epub 2019 Feb 14. Biochim Biophys Acta Biomembr. 2019. PMID: 30772281 Free PMC article.
29 results