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Page 1
Optimization of LpxC Inhibitors for Antibacterial Activity and Cardiovascular Safety.
Cohen F, Aggen JB, Andrews LD, Assar Z, Boggs J, Choi T, Dozzo P, Easterday AN, Haglund CM, Hildebrandt DJ, Holt MC, Joly K, Jubb A, Kamal Z, Kane TR, Konradi AW, Krause KM, Linsell MS, Machajewski TD, Miroshnikova O, Moser HE, Nieto V, Phan T, Plato C, Serio AW, Seroogy J, Shakhmin A, Stein AJ, Sun AD, Sviridov S, Wang Z, Wlasichuk K, Yang W, Zhou X, Zhu H, Cirz RT. Cohen F, et al. Among authors: linsell ms. ChemMedChem. 2019 Aug 20;14(16):1560-1572. doi: 10.1002/cmdc.201900287. Epub 2019 Aug 5. ChemMedChem. 2019. PMID: 31283109
Synthesis and spectrum of the neoglycoside ACHN-490.
Aggen JB, Armstrong ES, Goldblum AA, Dozzo P, Linsell MS, Gliedt MJ, Hildebrandt DJ, Feeney LA, Kubo A, Matias RD, Lopez S, Gomez M, Wlasichuk KB, Diokno R, Miller GH, Moser HE. Aggen JB, et al. Among authors: linsell ms. Antimicrob Agents Chemother. 2010 Nov;54(11):4636-42. doi: 10.1128/AAC.00572-10. Epub 2010 Aug 30. Antimicrob Agents Chemother. 2010. PMID: 20805391 Free PMC article.
Synthesis and Microbiological Evaluation of Novel Tetracyclic Fluoroquinolones.
Wagman AS, Cirz R, McEnroe G, Aggen J, Linsell MS, Goldblum AA, Lopez S, Gomez M, Miller G, Simons LJ, Belliotti TR, Harris CR, Poel TJ, Melnick MJ, Gaston RD, Moser HE. Wagman AS, et al. Among authors: linsell ms. ChemMedChem. 2017 Oct 20;12(20):1687-1692. doi: 10.1002/cmdc.201700426. Epub 2017 Oct 2. ChemMedChem. 2017. PMID: 28881459
Optimization and Mechanistic Characterization of Pyridopyrimidine Inhibitors of Bacterial Biotin Carboxylase.
Andrews LD, Kane TR, Dozzo P, Haglund CM, Hilderbrandt DJ, Linsell MS, Machajewski T, McEnroe G, Serio AW, Wlasichuk KB, Neau DB, Pakhomova S, Waldrop GL, Sharp M, Pogliano J, Cirz RT, Cohen F. Andrews LD, et al. Among authors: linsell ms. J Med Chem. 2019 Aug 22;62(16):7489-7505. doi: 10.1021/acs.jmedchem.9b00625. Epub 2019 Aug 9. J Med Chem. 2019. PMID: 31306011 Free PMC article.
Toward Overcoming Staphylococcus aureus Aminoglycoside Resistance Mechanisms with a Functionally Designed Neomycin Analogue.
Hanessian S, Giguère A, Grzyb J, Maianti JP, Saavedra OM, Aggen JB, Linsell MS, Goldblum AA, Hildebrandt DJ, Kane TR, Dozzo P, Gliedt MJ, Matias RD, Feeney LA, Armstrong ES. Hanessian S, et al. Among authors: linsell ms. ACS Med Chem Lett. 2011 Sep 29;2(12):924-8. doi: 10.1021/ml200202y. eCollection 2011 Dec 8. ACS Med Chem Lett. 2011. PMID: 24900282 Free PMC article.
A multivalent approach to drug discovery for novel antibiotics.
Long DD, Aggen JB, Christensen BG, Judice JK, Hegde SS, Kaniga K, Krause KM, Linsell MS, Moran EJ, Pace JL. Long DD, et al. Among authors: linsell ms. J Antibiot (Tokyo). 2008 Oct;61(10):595-602. doi: 10.1038/ja.2008.79. J Antibiot (Tokyo). 2008. PMID: 19168973
Exploring the positional attachment of glycopeptide/beta-lactam heterodimers.
Long DD, Aggen JB, Chinn J, Choi SK, Christensen BG, Fatheree PR, Green D, Hegde SS, Judice JK, Kaniga K, Krause KM, Leadbetter M, Linsell MS, Marquess DG, Moran EJ, Nodwell MB, Pace JL, Trapp SG, Turner SD. Long DD, et al. Among authors: linsell ms. J Antibiot (Tokyo). 2008 Oct;61(10):603-14. doi: 10.1038/ja.2008.80. J Antibiot (Tokyo). 2008. PMID: 19168974
Hydrophobic vancomycin derivatives with improved ADME properties: discovery of telavancin (TD-6424).
Leadbetter MR, Adams SM, Bazzini B, Fatheree PR, Karr DE, Krause KM, Lam BM, Linsell MS, Nodwell MB, Pace JL, Quast K, Shaw JP, Soriano E, Trapp SG, Villena JD, Wu TX, Christensen BG, Judice JK. Leadbetter MR, et al. Among authors: linsell ms. J Antibiot (Tokyo). 2004 May;57(5):326-36. doi: 10.7164/antibiotics.57.326. J Antibiot (Tokyo). 2004. PMID: 15303493 Free article.
11 results