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GCDCA down-regulates gene expression by increasing Sp1 binding to the NOS-3 promoter in an oxidative stress dependent manner.
González-Rubio S, López-Sánchez L, Muñoz-Castañeda J, Linares CI, Aguilar-Melero P, Rodríguez-Perálvarez M, Sánchez-Sánchez R, Fernández-Álvarez A, Casado M, Montero-Álvarez JL, Rodríguez-Ariza A, Muntané J, de la Mata M, Ferrín G. González-Rubio S, et al. Among authors: linares ci. Biochem Pharmacol. 2015 Jul 1;96(1):39-51. doi: 10.1016/j.bcp.2015.04.017. Epub 2015 Apr 27. Biochem Pharmacol. 2015. PMID: 25931146
Calcium-dependent nitric oxide production is involved in the cytoprotective properties of n-acetylcysteine in glycochenodeoxycholic acid-induced cell death in hepatocytes.
González-Rubio S, Linares CI, Bello RI, González R, Ferrín G, Hidalgo AB, Muñoz-Gomariz E, Rodríguez BA, Barrera P, Ranchal I, Durán-Prado M, Aguilar-Melero P, De la Mata M, Muntané J. González-Rubio S, et al. Among authors: linares ci. Toxicol Appl Pharmacol. 2010 Jan 15;242(2):165-72. doi: 10.1016/j.taap.2009.10.003. Epub 2009 Oct 23. Toxicol Appl Pharmacol. 2010. PMID: 19837105
Mitochondrial-driven ubiquinone enhances extracellular calcium-dependent nitric oxide production and reduces glycochenodeoxycholic acid-induced cell death in hepatocytes.
González-Rubio S, Hidalgo AB, Ferrín G, Bello RI, González R, Gahete MD, Ranchal I, Rodríguez BA, Barrera P, Aguilar-Melero P, Linares CI, Castaño JP, Victor VM, De la Mata M, Muntané J. González-Rubio S, et al. Among authors: linares ci. Chem Res Toxicol. 2009 Dec;22(12):1984-91. doi: 10.1021/tx900327t. Chem Res Toxicol. 2009. PMID: 20020783
Mitochondrial drug targets in cell death and cancer.
Ferrín G, Linares CI, Muntané J. Ferrín G, et al. Among authors: linares ci. Curr Pharm Des. 2011;17(20):2002-16. doi: 10.2174/138161211796904803. Curr Pharm Des. 2011. PMID: 21718250 Review.
Targeting hepatoma using nitric oxide donor strategies.
González R, Ferrín G, Aguilar-Melero P, Ranchal I, Linares CI, Bello RI, De la Mata M, Gogvadze V, Bárcena JA, Alamo JM, Orrenius S, Padillo FJ, Zhivotovsky B, Muntané J. González R, et al. Among authors: linares ci. Antioxid Redox Signal. 2013 Feb 10;18(5):491-506. doi: 10.1089/ars.2011.4476. Epub 2012 Sep 26. Antioxid Redox Signal. 2013. PMID: 22861189
Sensitivity to anti-Fas is independent of increased cathepsin D activity and adrenodoxin reductase expression occurring in NOS-3 overexpressing HepG2 cells.
Linares CI, Ferrín G, Aguilar-Melero P, González-Rubio S, Rodríguez-Perálvarez M, Sánchez-Aragó M, Chicano-Gálvez E, Cuezva JM, Montero-Álvarez JL, Muntané J, de la Mata M. Linares CI, et al. Biochim Biophys Acta. 2015 May;1853(5):1182-94. doi: 10.1016/j.bbamcr.2015.02.015. Epub 2015 Feb 21. Biochim Biophys Acta. 2015. PMID: 25712867 Free article.
Plasma protein biomarkers of hepatocellular carcinoma in HCV-infected alcoholic patients with cirrhosis.
Ferrín G, Rodríguez-Perálvarez M, Aguilar-Melero P, Ranchal I, Llamoza C, Linares CI, González-Rubio S, Muntané J, Briceño J, López-Cillero P, Montero-Álvarez JL, de la Mata M. Ferrín G, et al. Among authors: linares ci. PLoS One. 2015 Mar 19;10(3):e0118527. doi: 10.1371/journal.pone.0118527. eCollection 2015. PLoS One. 2015. PMID: 25789864 Free PMC article.
13 results