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Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike-ACE2 Interaction.
Guimond SE, Mycroft-West CJ, Gandhi NS, Tree JA, Le TT, Spalluto CM, Humbert MV, Buttigieg KR, Coombes N, Elmore MJ, Wand M, Nyström K, Said J, Setoh YX, Amarilla AA, Modhiran N, Sng JDJ, Chhabra M, Young PR, Rawle DJ, Lima MA, Yates EA, Karlsson R, Miller RL, Chen YH, Bagdonaite I, Yang Z, Stewart J, Nguyen D, Laidlaw S, Hammond E, Dredge K, Wilkinson TMA, Watterson D, Khromykh AA, Suhrbier A, Carroll MW, Trybala E, Bergström T, Ferro V, Skidmore MA, Turnbull JE. Guimond SE, et al. Among authors: lima ma. ACS Cent Sci. 2022 May 25;8(5):527-545. doi: 10.1021/acscentsci.1c01293. Epub 2022 Mar 29. ACS Cent Sci. 2022. PMID: 35647275 Free PMC article.
A non-hemorrhagic hybrid heparin/heparan sulfate with anticoagulant potential.
Brito AS, Cavalcante RS, Palhares LC, Hughes AJ, Andrade GP, Yates EA, Nader HB, Lima MA, Chavante SF. Brito AS, et al. Among authors: lima ma. Carbohydr Polym. 2014 Jan;99:372-8. doi: 10.1016/j.carbpol.2013.08.063. Epub 2013 Aug 29. Carbohydr Polym. 2014. PMID: 24274520 Free article.
Heparan sulfate and heparin interactions with proteins.
Meneghetti MC, Hughes AJ, Rudd TR, Nader HB, Powell AK, Yates EA, Lima MA. Meneghetti MC, et al. Among authors: lima ma. J R Soc Interface. 2015 Sep 6;12(110):0589. doi: 10.1098/rsif.2015.0589. J R Soc Interface. 2015. PMID: 26289657 Free PMC article. Review.
Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells.
Ghezzi S, Cooper L, Rubio A, Pagani I, Capobianchi MR, Ippolito G, Pelletier J, Meneghetti MCZ, Lima MA, Skidmore MA, Broccoli V, Yates EA, Vicenzi E. Ghezzi S, et al. Among authors: lima ma. Antiviral Res. 2017 Apr;140:13-17. doi: 10.1016/j.antiviral.2016.12.023. Epub 2017 Jan 5. Antiviral Res. 2017. PMID: 28063994 Free PMC article.
604 results