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Marinobufagin, a molecule from poisonous frogs, causes biochemical, morphological and cell cycle changes in human neoplasms and vegetal cells.
Machado KDC, Sousa LQ, Lima DJB, Soares BM, Cavalcanti BC, Maranhão SS, Noronha JDC, Rodrigues DJ, Militão GCG, Chaves MH, Vieira-Júnior GM, Pessoa C, Moraes MO, Sousa JMCE, Melo-Cavalcante AAC, Ferreira PMP. Machado KDC, et al. Among authors: lima djb. Toxicol Lett. 2018 Mar 15;285:121-131. doi: 10.1016/j.toxlet.2017.12.018. Epub 2017 Dec 26. Toxicol Lett. 2018. PMID: 29287997
Synthesis of PJOV56, a new quinoxalinyl-hydrazone derivative able to induce autophagy and apoptosis in colorectal cancer cells, and related compounds.
Maranhão SS, Moura AF, Oliveira ACA, Lima DJB, Barros-Nepomuceno FWA, Paier CRK, Pinheiro AC, Nogueira TCM, de Souza MVN, Pessoa C. Maranhão SS, et al. Among authors: lima djb. Bioorg Med Chem Lett. 2020 Jan 15;30(2):126851. doi: 10.1016/j.bmcl.2019.126851. Epub 2019 Dec 3. Bioorg Med Chem Lett. 2020. PMID: 31836446
Toxicological, chemopreventive, and cytotoxic potentialities of rare vegetal species and supporting findings for the Brazilian Unified Health System (SUS).
Silva JDN, Monção NBN, de Farias RRS, Citó AMDGL, Chaves MH, Araújo MRS, Lima DJB, Pessoa C, Lima A, Araújo ECDC, Militão GCG, Costa MPD, Capasso R, Ferreira PMP. Silva JDN, et al. Among authors: lima djb. J Toxicol Environ Health A. 2020 Jul 17;83(13-14):525-545. doi: 10.1080/15287394.2020.1780658. Epub 2020 Jun 22. J Toxicol Environ Health A. 2020. PMID: 32568625
Toxic profile of marinobufagin from poisonous Amazon toads and antitumoral effects on human colorectal carcinomas.
Ferreira PMP, Sousa LQ, Sousa RWR, Rodrigues DJ, Monção Filho EDS, Chaves MH, Vieira Júnior GM, Rizzo MDS, Filgueiras LA, Mendes AN, Lima DJB, Pessoa C, Sousa JMCE, Rodrigues ACBDC, Soares MBP, Bezerra DP. Ferreira PMP, et al. Among authors: lima djb. J Ethnopharmacol. 2023 Jun 28;310:116406. doi: 10.1016/j.jep.2023.116406. Epub 2023 Mar 23. J Ethnopharmacol. 2023. PMID: 36965547
It takes two to tango: synthesis of cytotoxic quinones containing two redox active centers with potential antitumor activity.
Lima DJB, Almeida RG, Jardim GAM, Barbosa BPA, Santos ACC, Valença WO, Scheide MR, Gatto CC, de Carvalho GGC, Costa PMS, Pessoa C, Pereira CLM, Jacob C, Braga AL, da Silva Júnior EN. Lima DJB, et al. RSC Med Chem. 2021 Aug 12;12(10):1709-1721. doi: 10.1039/d1md00168j. eCollection 2021 Oct 20. RSC Med Chem. 2021. PMID: 34778772 Free PMC article.
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