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Dual blockade of IL-4 and IL-13 with dupilumab, an IL-4Rα antibody, is required to broadly inhibit type 2 inflammation.
Le Floc'h A, Allinne J, Nagashima K, Scott G, Birchard D, Asrat S, Bai Y, Lim WK, Martin J, Huang T, Potocky TB, Kim JH, Rafique A, Papadopoulos NJ, Stahl N, Yancopoulos GD, Murphy AJ, Sleeman MA, Orengo JM. Le Floc'h A, et al. Among authors: lim wk. Allergy. 2020 May;75(5):1188-1204. doi: 10.1111/all.14151. Epub 2020 Jan 3. Allergy. 2020. PMID: 31838750 Free PMC article.
IL-33 blockade affects mediators of persistence and exacerbation in a model of chronic airway inflammation.
Allinne J, Scott G, Lim WK, Birchard D, Erjefält JS, Sandén C, Ben LH, Agrawal A, Kaur N, Kim JH, Kamat V, Fury W, Huang T, Stahl N, Yancopoulos GD, Murphy AJ, Sleeman MA, Orengo JM. Allinne J, et al. Among authors: lim wk. J Allergy Clin Immunol. 2019 Dec;144(6):1624-1637.e10. doi: 10.1016/j.jaci.2019.08.039. Epub 2019 Sep 25. J Allergy Clin Immunol. 2019. PMID: 31562870 Free article.
Activin A does not drive post-traumatic heterotopic ossification.
Hwang C, Pagani CA, Das N, Marini S, Huber AK, Xie L, Jimenez J, Brydges S, Lim WK, Nannuru KC, Murphy AJ, Economides AN, Hatsell SJ, Levi B. Hwang C, et al. Among authors: lim wk. Bone. 2020 Sep;138:115473. doi: 10.1016/j.bone.2020.115473. Epub 2020 Jun 15. Bone. 2020. PMID: 32553795
Enhanced IL-36R signaling promotes barrier impairment and inflammation in skin and intestine.
Hovhannisyan Z, Liu N, Khalil-Aguero S, Panea C, VanValkenburgh J, Zhang R, Lim WK, Bai Y, Fury W, Huang T, Garnova E, Fairhurst J, Kim J, Aryal S, Ajithdoss D, Oyejide A, Del Pilar Molina-Portela M, E H, Poueymirou W, Oristian NS, Brydges S, Liu X, Olson W, Yancopoulos G, Murphy AJ, Sleeman MA, Haxhinasto S. Hovhannisyan Z, et al. Among authors: lim wk. Sci Immunol. 2020 Dec 18;5(54):eaax1686. doi: 10.1126/sciimmunol.aax1686. Sci Immunol. 2020. PMID: 33443029
Comparison of the Inflammatory Circuits in Psoriasis Vulgaris, Non‒Pustular Palmoplantar Psoriasis, and Palmoplantar Pustular Psoriasis.
Wang CQ, Haxhinasto S, Garcet S, Kunjravia N, Cueto I, Gonzalez J, Rambhia D, Harari O, Sleeman MA, Hamilton JD, Lim WK, Freudenberg J, Kalliolias GD, Thakker P, Bissonnette R, Krueger JG. Wang CQ, et al. Among authors: lim wk. J Invest Dermatol. 2023 Jan;143(1):87-97.e14. doi: 10.1016/j.jid.2022.05.1094. Epub 2022 Aug 5. J Invest Dermatol. 2023. PMID: 35934055 Free article.
Dupilumab in Adults and Adolescents with Eosinophilic Esophagitis.
Dellon ES, Rothenberg ME, Collins MH, Hirano I, Chehade M, Bredenoord AJ, Lucendo AJ, Spergel JM, Aceves S, Sun X, Kosloski MP, Kamal MA, Hamilton JD, Beazley B, McCann E, Patel K, Mannent LP, Laws E, Akinlade B, Amin N, Lim WK, Wipperman MF, Ruddy M, Patel N, Weinreich DR, Yancopoulos GD, Shumel B, Maloney J, Giannelou A, Shabbir A. Dellon ES, et al. Among authors: lim wk. N Engl J Med. 2022 Dec 22;387(25):2317-2330. doi: 10.1056/NEJMoa2205982. N Engl J Med. 2022. PMID: 36546624 Clinical Trial.
Blocking common γ chain cytokine signaling ameliorates T cell-mediated pathogenesis in disease models.
Le Floc'h A, Nagashima K, Birchard D, Scott G, Ben LH, Ajithdoss D, Gayvert K, Romero Hernandez A, Herbin O, Tay A, Farrales P, Korgaonkar CK, Pan H, Shah S, Kamat V, Chatterjee I, Popke J, Oyejide A, Lim WK, Kim JH, Huang T, Franklin M, Olson W, Norton T, Perlee L, Yancopoulos GD, Murphy AJ, Sleeman MA, Orengo JM. Le Floc'h A, et al. Among authors: lim wk. Sci Transl Med. 2023 Jan 11;15(678):eabo0205. doi: 10.1126/scitranslmed.abo0205. Epub 2023 Jan 11. Sci Transl Med. 2023. PMID: 36630481
Autoantibodies are associated with disease progression in idiopathic pulmonary fibrosis.
Koether K, Besnard V, Sandig H, Carruthers A, Miranda E, Grootenboer-Mignot S, Taillé C, Chevret S, Valeyre D, Nunes H, Israel-Biet D, Lim WK, Cottin V, Corkill D, Dobson C, Groves M, Ferraro F, Guenzi E, Huang L, Sulikowski M, Mailleux A, Murray LA, Mustelin T, Strickland I, Sleeman MA, Crestani B. Koether K, et al. Among authors: lim wk. Eur Respir J. 2023 May 18;61(5):2102381. doi: 10.1183/13993003.02381-2021. Print 2023 May. Eur Respir J. 2023. PMID: 37080573
TRAPnSeq allows high-throughput profiling of antigen-specific antibody-secreting cells.
Asrat S, Devlin JC, Vecchione A, Klotz B, Setliff I, Srivastava D, Limnander A, Rafique A, Adler C, Porter S, Murphy AJ, Atwal GS, Sleeman MA, Lim WK, Orengo JM. Asrat S, et al. Among authors: lim wk. Cell Rep Methods. 2023 Jul 7;3(7):100522. doi: 10.1016/j.crmeth.2023.100522. eCollection 2023 Jul 24. Cell Rep Methods. 2023. PMID: 37533642 Free PMC article.
339 results