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Activation of pruritogenic TGR5, MrgprA3, and MrgprC11 on colon-innervating afferents induces visceral hypersensitivity.
Castro J, Harrington AM, Lieu T, Garcia-Caraballo S, Maddern J, Schober G, O'Donnell T, Grundy L, Lumsden AL, Miller P, Ghetti A, Steinhoff MS, Poole DP, Dong X, Chang L, Bunnett NW, Brierley SM. Castro J, et al. Among authors: lieu t. JCI Insight. 2019 Oct 17;4(20):e131712. doi: 10.1172/jci.insight.131712. JCI Insight. 2019. PMID: 31536477 Free PMC article.
Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome.
Jimenez-Vargas NN, Pattison LA, Zhao P, Lieu T, Latorre R, Jensen DD, Castro J, Aurelio L, Le GT, Flynn B, Herenbrink CK, Yeatman HR, Edgington-Mitchell L, Porter CJH, Halls ML, Canals M, Veldhuis NA, Poole DP, McLean P, Hicks GA, Scheff N, Chen E, Bhattacharya A, Schmidt BL, Brierley SM, Vanner SJ, Bunnett NW. Jimenez-Vargas NN, et al. Among authors: lieu t. Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):E7438-E7447. doi: 10.1073/pnas.1721891115. Epub 2018 Jul 16. Proc Natl Acad Sci U S A. 2018. PMID: 30012612 Free PMC article.
The TGR5 receptor mediates bile acid-induced itch and analgesia.
Alemi F, Kwon E, Poole DP, Lieu T, Lyo V, Cattaruzza F, Cevikbas F, Steinhoff M, Nassini R, Materazzi S, Guerrero-Alba R, Valdez-Morales E, Cottrell GS, Schoonjans K, Geppetti P, Vanner SJ, Bunnett NW, Corvera CU. Alemi F, et al. Among authors: lieu t. J Clin Invest. 2013 Apr;123(4):1513-30. doi: 10.1172/JCI64551. Epub 2013 Mar 25. J Clin Invest. 2013. PMID: 23524965 Free PMC article.
The bile acid receptor TGR5 activates the TRPA1 channel to induce itch in mice.
Lieu T, Jayaweera G, Zhao P, Poole DP, Jensen D, Grace M, McIntyre P, Bron R, Wilson YM, Krappitz M, Haerteis S, Korbmacher C, Steinhoff MS, Nassini R, Materazzi S, Geppetti P, Corvera CU, Bunnett NW. Lieu T, et al. Gastroenterology. 2014 Dec;147(6):1417-28. doi: 10.1053/j.gastro.2014.08.042. Epub 2014 Sep 3. Gastroenterology. 2014. PMID: 25194674 Free PMC article.
G-CSF Receptor Blockade Ameliorates Arthritic Pain and Disease.
Lee MC, McCubbin JA, Christensen AD, Poole DP, Rajasekhar P, Lieu T, Bunnett NW, Garcia-Caraballo S, Erickson A, Brierley SM, Saleh R, Achuthan A, Fleetwood AJ, Anderson RL, Hamilton JA, Cook AD. Lee MC, et al. Among authors: lieu t. J Immunol. 2017 May 1;198(9):3565-3575. doi: 10.4049/jimmunol.1602127. Epub 2017 Mar 20. J Immunol. 2017. PMID: 28320832 Free PMC article.
308 results