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Synthesis and Biological Evaluation of New Antitubulin Agents Containing 2-(3',4',5'-trimethoxyanilino)-3,6-disubstituted-4,5,6,7-tetrahydrothieno[2,3-c]pyridine Scaffold.
Romagnoli R, Prencipe F, Oliva P, Cacciari B, Balzarini J, Liekens S, Hamel E, Brancale A, Ferla S, Manfredini S, Zurlo M, Finotti A, Gambari R. Romagnoli R, et al. Among authors: liekens s. Molecules. 2020 Apr 7;25(7):1690. doi: 10.3390/molecules25071690. Molecules. 2020. PMID: 32272719 Free PMC article.
2-Alkoxycarbonyl-3-arylamino-5-substituted thiophenes as a novel class of antimicrotubule agents: Design, synthesis, cell growth and tubulin polymerization inhibition.
Romagnoli R, Kimatrai Salvador M, Schiaffino Ortega S, Baraldi PG, Oliva P, Baraldi S, Lopez-Cara LC, Brancale A, Ferla S, Hamel E, Balzarini J, Liekens S, Mattiuzzo E, Basso G, Viola G. Romagnoli R, et al. Among authors: liekens s. Eur J Med Chem. 2018 Jan 1;143:683-698. doi: 10.1016/j.ejmech.2017.11.096. Eur J Med Chem. 2018. PMID: 29220790 Free PMC article.
Design, synthesis and biological evaluation of 2-alkoxycarbonyl-3-anilinoindoles as a new class of potent inhibitors of tubulin polymerization.
Romagnoli R, Prencipe F, Oliva P, Kimatrai Salvador M, Brancale A, Ferla S, Hamel E, Viola G, Bortolozzi R, Persoons L, Balzarini J, Liekens S, Schols D. Romagnoli R, et al. Among authors: liekens s. Bioorg Chem. 2020 Apr;97:103665. doi: 10.1016/j.bioorg.2020.103665. Epub 2020 Feb 18. Bioorg Chem. 2020. PMID: 32086053 Free article.
Design, synthesis, in vitro antiproliferative activity and apoptosis-inducing studies of 1-(3',4',5'-trimethoxyphenyl)-3-(2'-alkoxycarbonylindolyl)-2-propen-1-one derivatives obtained by a molecular hybridisation approach.
Preti D, Romagnoli R, Rondanin R, Cacciari B, Hamel E, Balzarini J, Liekens S, Schols D, Estévez-Sarmiento F, Quintana J, Estévez F. Preti D, et al. Among authors: liekens s. J Enzyme Inhib Med Chem. 2018 Dec;33(1):1225-1238. doi: 10.1080/14756366.2018.1493473. J Enzyme Inhib Med Chem. 2018. PMID: 30141353 Free PMC article.
142 results