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Evolutionarily conserved Galphabetagamma binding surfaces support a model of the G protein-receptor complex.
Lichtarge O, Bourne HR, Cohen FE. Lichtarge O, et al. Proc Natl Acad Sci U S A. 1996 Jul 23;93(15):7507-11. doi: 10.1073/pnas.93.15.7507. Proc Natl Acad Sci U S A. 1996. PMID: 8755504 Free PMC article.
Nonetheless, the locations of the receptors and effector binding sites remain poorly characterized, although nearly complete structures of the alphabetagamma heterotrimeric complex are available. Here we apply evolutionary trace (ET) analysis [Lichtarge, O., Bourne, …
Nonetheless, the locations of the receptors and effector binding sites remain poorly characterized, although nearly complete structures of t …
Similar structures and shared switch mechanisms of the beta2-adrenoceptor and the parathyroid hormone receptor. Zn(II) bridges between helices III and VI block activation.
Sheikh SP, Vilardarga JP, Baranski TJ, Lichtarge O, Iiri T, Meng EC, Nissenson RA, Bourne HR. Sheikh SP, et al. Among authors: lichtarge o. J Biol Chem. 1999 Jun 11;274(24):17033-41. doi: 10.1074/jbc.274.24.17033. J Biol Chem. 1999. PMID: 10358054 Free article.
By substituting histidines for residues at the cytoplasmic ends of helices III and VI in retinal rhodopsin, we engineered a metal-binding site whose occupancy by Zn(II) prevented the receptor from activating a retinal G protein, Gt (Sheikh, S. P., Zvyaga, T. A. , Lichtarge …
By substituting histidines for residues at the cytoplasmic ends of helices III and VI in retinal rhodopsin, we engineered a metal-binding si …
Genetic mapping of the human C5a receptor. Identification of transmembrane amino acids critical for receptor function.
Geva A, Lassere TB, Lichtarge O, Pollitt SK, Baranski TJ. Geva A, et al. Among authors: lichtarge o. J Biol Chem. 2000 Nov 10;275(45):35393-401. doi: 10.1074/jbc.M005602200. J Biol Chem. 2000. PMID: 10952985 Free article.
Previously, we used random saturation mutagenesis coupled with a genetic selection in yeast to determine the relative importance of amino acids in four of the seven transmembrane segments of the human C5a receptor (Baranski, T. J., Herzmark, P., Lichtarge, O., Gerbe …
Previously, we used random saturation mutagenesis coupled with a genetic selection in yeast to determine the relative importance of amino ac …
193 results