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Metabolomics and integrated network pharmacology analysis reveal Tricin as the active anti-cancer component of Weijing decoction by suppression of PRKCA and sphingolipid signaling.
Li JX, Li RZ, Sun A, Zhou H, Neher E, Yang JS, Huang JM, Zhang YZ, Jiang ZB, Liang TL, Ma LR, Wang J, Wang XR, Fan XQ, Huang J, Xie Y, Liu L, Tang L, Leung EL, Yan PY. Li JX, et al. Among authors: liang tl. Pharmacol Res. 2021 Sep;171:105574. doi: 10.1016/j.phrs.2021.105574. Epub 2021 Jul 25. Pharmacol Res. 2021. PMID: 34419228
CERS4 predicts positive anti-PD-1 response and promotes immunomodulation through Rhob-mediated suppression of CD8+Tim3+ exhausted T cells in non-small cell lung cancer.
Wang J, Li RZ, Wang WJ, Pan HD, Xie C, Yau LF, Wang XX, Long WL, Chen RH, Liang TL, Ma LR, Li JX, Huang JM, Wu QB, Liu L, He JX, Leung EL. Wang J, et al. Among authors: liang tl. Pharmacol Res. 2023 Aug;194:106850. doi: 10.1016/j.phrs.2023.106850. Epub 2023 Jul 13. Pharmacol Res. 2023. PMID: 37453674 Free article.
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