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IL-37 protects against obesity-induced inflammation and insulin resistance.
Ballak DB, van Diepen JA, Moschen AR, Jansen HJ, Hijmans A, Groenhof GJ, Leenders F, Bufler P, Boekschoten MV, Müller M, Kersten S, Li S, Kim S, Eini H, Lewis EC, Joosten LA, Tilg H, Netea MG, Tack CJ, Dinarello CA, Stienstra R. Ballak DB, et al. Among authors: li s. Nat Commun. 2014 Sep 3;5:4711. doi: 10.1038/ncomms5711. Nat Commun. 2014. PMID: 25182023 Free article.
IL-37 inhibits inflammasome activation and disease severity in murine aspergillosis.
Moretti S, Bozza S, Oikonomou V, Renga G, Casagrande A, Iannitti RG, Puccetti M, Garlanda C, Kim S, Li S, van de Veerdonk FL, Dinarello CA, Romani L. Moretti S, et al. Among authors: li s. PLoS Pathog. 2014 Nov 6;10(11):e1004462. doi: 10.1371/journal.ppat.1004462. eCollection 2014 Nov. PLoS Pathog. 2014. PMID: 25375146 Free PMC article.
IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction.
Nold-Petry CA, Lo CY, Rudloff I, Elgass KD, Li S, Gantier MP, Lotz-Havla AS, Gersting SW, Cho SX, Lao JC, Ellisdon AM, Rotter B, Azam T, Mangan NE, Rossello FJ, Whisstock JC, Bufler P, Garlanda C, Mantovani A, Dinarello CA, Nold MF. Nold-Petry CA, et al. Among authors: li s. Nat Immunol. 2015 Apr;16(4):354-65. doi: 10.1038/ni.3103. Epub 2015 Mar 2. Nat Immunol. 2015. PMID: 25729923
Suppression of innate inflammation and immunity by interleukin-37.
Dinarello CA, Nold-Petry C, Nold M, Fujita M, Li S, Kim S, Bufler P. Dinarello CA, et al. Among authors: li s. Eur J Immunol. 2016 May;46(5):1067-81. doi: 10.1002/eji.201545828. Eur J Immunol. 2016. PMID: 27060871 Free PMC article. Review.
Interleukin-37 suppresses the osteogenic responses of human aortic valve interstitial cells in vitro and alleviates valve lesions in mice.
Zeng Q, Song R, Fullerton DA, Ao L, Zhai Y, Li S, Ballak DB, Cleveland JC Jr, Reece TB, McKinsey TA, Xu D, Dinarello CA, Meng X. Zeng Q, et al. Among authors: li s. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1631-1636. doi: 10.1073/pnas.1619667114. Epub 2017 Jan 30. Proc Natl Acad Sci U S A. 2017. PMID: 28137840 Free PMC article.
Interleukin-37 treatment of mice with metabolic syndrome improves insulin sensitivity and reduces pro-inflammatory cytokine production in adipose tissue.
Ballak DB, Li S, Cavalli G, Stahl JL, Tengesdal IW, van Diepen JA, Klück V, Swartzwelter B, Azam T, Tack CJ, Stienstra R, Mandrup-Poulsen T, Seals DR, Dinarello CA. Ballak DB, et al. Among authors: li s. J Biol Chem. 2018 Sep 14;293(37):14224-14236. doi: 10.1074/jbc.RA118.003698. Epub 2018 Jul 13. J Biol Chem. 2018. PMID: 30006351 Free PMC article.
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