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Chronic cough relief by allosteric modulation of P2X3 without taste disturbance.
Guo CR, Zhang ZZ, Zhou X, Sun MY, Li TT, Lei YT, Gao YH, Li QQ, Yue CX, Gao Y, Lin YY, Hao CY, Li CZ, Cao P, Zhu MX, Rong MQ, Wang WH, Yu Y. Guo CR, et al. Among authors: li tt, li qq, li cz. Nat Commun. 2023 Sep 20;14(1):5844. doi: 10.1038/s41467-023-41495-0. Nat Commun. 2023. PMID: 37730705 Free PMC article.
GSK1702934A and M085 directly activate TRPC6 via a mechanism of stimulating the extracellular cavity formed by the pore helix and transmembrane helix S6.
Yang PL, Li XH, Wang J, Ma XF, Zhou BY, Jiao YF, Wang WH, Cao P, Zhu MX, Li PW, Xiao ZH, Li CZ, Guo CR, Lei YT, Yu Y. Yang PL, et al. Among authors: li xh, li pw, li cz. J Biol Chem. 2021 Oct;297(4):101125. doi: 10.1016/j.jbc.2021.101125. Epub 2021 Aug 28. J Biol Chem. 2021. PMID: 34461094 Free PMC article.
Vanilloid agonist-mediated activation of TRPV1 channels requires coordinated movement of the S1-S4 bundle rather than a quiescent state.
Sun MY, Zhang X, Yu PC, Liu D, Yang Y, Cui WW, Yang XN, Lei YT, Li XH, Wang WH, Cao P, Wang HS, Zhu MX, Li CZ, Wang R, Fan YZ, Yu Y. Sun MY, et al. Among authors: li xh, li cz. Sci Bull (Beijing). 2022 May 30;67(10):1062-1076. doi: 10.1016/j.scib.2022.02.016. Epub 2022 Mar 1. Sci Bull (Beijing). 2022. PMID: 36546250 Free article.
A shared mechanism for TNP-ATP recognition by members of the P2X receptor family.
Ma XB, Yue CX, Liu Y, Yang Y, Wang J, Yang XN, Huang LD, Zhu MX, Hattori M, Li CZ, Yu Y, Guo CR. Ma XB, et al. Among authors: li cz. Comput Struct Biotechnol J. 2023 Dec 7;23:295-308. doi: 10.1016/j.csbj.2023.12.005. eCollection 2024 Dec. Comput Struct Biotechnol J. 2023. PMID: 38173879 Free PMC article.
616 results