Lewin NE - Search Results

1

2-Sulfonamidopyridine C-region analogs of 2-(3-fluoro-4-methylsulfonamidophenyl)propanamides as potent TRPV1 antagonists.

Ann J, Ki Y, Yoon S, Kim MS, Lee JU, Kim C, Lee S, Jung A, Baek J, Hong S, Choi S, Pearce LV, Esch TE, Turcios NA, Lewin NE, Ogunjirin AE, Herold BK, McCall AK, Blumberg PM, Lee J. Ann J, et al. Among authors: lewin ne. Bioorg Med Chem. 2016 Mar 15;24(6):1231-40. doi: 10.1016/j.bmc.2016.01.051. Epub 2016 Jan 28. Bioorg Med Chem. 2016. PMID: 26860926 Free PMC article.

2

Conformationally constrained analogues of diacylglycerol (DAG). Effect on protein kinase C (PK-C) binding by the isosteric replacement of sn-1 and sn-2 esters in DAG-lactones.

Kang JH, Chung HE, Kim SY, Kim Y, Lee J, Lewin NE, Pearce LV, Blumberg PM, Marquez VE. Kang JH, et al. Among authors: lewin ne. Bioorg Med Chem. 2003 Jun 12;11(12):2529-39. doi: 10.1016/s0968-0896(03)00156-1. Bioorg Med Chem. 2003. PMID: 12757721

3

Macrocyclic diacylglycerol-bis-lactones as conformationally constrained analogues of diacylglycerol-lactones. Interactions with protein kinase C.

Kang JH, Kim SY, Lee J, Marquez VE, Lewin NE, Pearce LV, Blumberg PM. Kang JH, et al. Among authors: lewin ne. J Med Chem. 2004 Jul 29;47(16):4000-7. doi: 10.1021/jm0497747. J Med Chem. 2004. PMID: 15267238

4

2-Benzyl and 2-phenyl-3-hydroxypropyl pivalates as protein kinase C ligands.

Lee J, Lee JH, Kim SY, Perry NA, Lewin NE, Ayres JA, Blumberg PM. Lee J, et al. Among authors: lewin ne. Bioorg Med Chem. 2006 Mar 15;14(6):2022-31. doi: 10.1016/j.bmc.2005.10.051. Epub 2005 Nov 15. Bioorg Med Chem. 2006. PMID: 16297629

5

Branched diacylglycerol-lactones as potent protein kinase C ligands and alpha-secretase activators.

Lee J, Kang JH, Han KC, Kim Y, Kim SY, Youn HS, Mook-Jung I, Kim H, Lo Han JH, Ha HJ, Kim YH, Marquez VE, Lewin NE, Pearce LV, Lundberg DJ, Blumberg PM. Lee J, et al. Among authors: lewin ne. J Med Chem. 2006 Mar 23;49(6):2028-36. doi: 10.1021/jm0509391. J Med Chem. 2006. PMID: 16539391

6

Design and synthesis of protein kinase C epsilon selective diacylglycerol lactones (DAG-lactones).

Ann J, Yoon S, Baek J, Kim DH, Lewin NE, Hill CS, Blumberg PM, Lee J. Ann J, et al. Among authors: lewin ne. Eur J Med Chem. 2015 Jan 27;90:332-41. doi: 10.1016/j.ejmech.2014.11.025. Epub 2014 Nov 13. Eur J Med Chem. 2015. PMID: 25437619 Free PMC article.

7

Discovery of N-(3-fluoro-4-methylsulfonamidomethylphenyl)urea as a potent TRPV1 antagonistic template.

Ann J, Sun W, Zhou X, Jung A, Baek J, Lee S, Kim C, Yoon S, Hong S, Choi S, Turcios NA, Herold BK, Esch TE, Lewin NE, Abramovitz A, Pearce LV, Blumberg PM, Lee J. Ann J, et al. Among authors: lewin ne. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3603-7. doi: 10.1016/j.bmcl.2016.06.010. Epub 2016 Jun 7. Bioorg Med Chem Lett. 2016. PMID: 27317643 Free PMC article.

8

Discovery of dual-acting opioid ligand and TRPV1 antagonists as novel therapeutic agents for pain.

Lee H, Ahn S, Ann J, Ha H, Yoo YD, Kim YH, Hwang JY, Hur KH, Jang CG, Pearce LV, Esch TE, Lewin NE, Blumberg PM, Lee J. Lee H, et al. Among authors: lewin ne. Eur J Med Chem. 2019 Nov 15;182:111634. doi: 10.1016/j.ejmech.2019.111634. Epub 2019 Aug 21. Eur J Med Chem. 2019. PMID: 31472474 Free PMC article.

9

Conformationally constrained analogues of diacylglycerol. 19. Synthesis and protein kinase C binding affinity of diacylglycerol lactones bearing an N-hydroxylamide side chain.

Choi Y, Kang JH, Lewin NE, Blumberg PM, Lee J, Marquez VE. Choi Y, et al. Among authors: lewin ne. J Med Chem. 2003 Jun 19;46(13):2790-3. doi: 10.1021/jm030082c. J Med Chem. 2003. PMID: 12801241

10

Antineoplastic agents. 499. Synthesis of hystatin 2 and related 1H-benzo[de][1,6]-naphthyridinium salts from aaptamine.

Pettit GR, Hoffmann H, Herald DL, Blumberg PM, Hamel E, Schmidt JM, Chang Y, Pettit RK, Lewin NE, Pearce LV. Pettit GR, et al. Among authors: lewin ne. J Med Chem. 2004 Mar 25;47(7):1775-82. doi: 10.1021/jm030070r. J Med Chem. 2004. PMID: 15027869

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