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CRISPR-Cas9-mediated nuclear transport and genomic integration of nanostructured genes in human primary cells.
Lin-Shiao E, Pfeifer WG, Shy BR, Saffari Doost M, Chen E, Vykunta VS, Hamilton JR, Stahl EC, Lopez DM, Sandoval Espinoza CR, Deyanov AE, Lew RJ, Poirer MG, Marson A, Castro CE, Doudna JA. Lin-Shiao E, et al. Among authors: lew rj. Nucleic Acids Res. 2022 Feb 22;50(3):1256-1268. doi: 10.1093/nar/gkac049. Nucleic Acids Res. 2022. PMID: 35104875 Free PMC article.
Structural basis for AcrVA4 inhibition of specific CRISPR-Cas12a.
Knott GJ, Cress BF, Liu JJ, Thornton BW, Lew RJ, Al-Shayeb B, Rosenberg DJ, Hammel M, Adler BA, Lobba MJ, Xu M, Arkin AP, Fellmann C, Doudna JA. Knott GJ, et al. Among authors: lew rj. Elife. 2019 Aug 9;8:e49110. doi: 10.7554/eLife.49110. Elife. 2019. PMID: 31397669 Free PMC article.
Potent CRISPR-Cas9 inhibitors from Staphylococcus genomes.
Watters KE, Shivram H, Fellmann C, Lew RJ, McMahon B, Doudna JA. Watters KE, et al. Among authors: lew rj. Proc Natl Acad Sci U S A. 2020 Mar 24;117(12):6531-6539. doi: 10.1073/pnas.1917668117. Epub 2020 Mar 10. Proc Natl Acad Sci U S A. 2020. PMID: 32156733 Free PMC article.
Site-Specific Bioconjugation through Enzyme-Catalyzed Tyrosine-Cysteine Bond Formation.
Lobba MJ, Fellmann C, Marmelstein AM, Maza JC, Kissman EN, Robinson SA, Staahl BT, Urnes C, Lew RJ, Mogilevsky CS, Doudna JA, Francis MB. Lobba MJ, et al. Among authors: lew rj. ACS Cent Sci. 2020 Sep 23;6(9):1564-1571. doi: 10.1021/acscentsci.0c00940. Epub 2020 Aug 21. ACS Cent Sci. 2020. PMID: 32999931 Free PMC article.
Cancer-specific loss of TERT activation sensitizes glioblastoma to DNA damage.
Amen AM, Fellmann C, Soczek KM, Ren SM, Lew RJ, Knott GJ, Park JE, McKinney AM, Mancini A, Doudna JA, Costello JF. Amen AM, et al. Among authors: lew rj. Proc Natl Acad Sci U S A. 2021 Mar 30;118(13):e2008772118. doi: 10.1073/pnas.2008772118. Proc Natl Acad Sci U S A. 2021. PMID: 33758097 Free PMC article.
PI5P4Ks drive metabolic homeostasis through peroxisome-mitochondria interplay.
Ravi A, Palamiuc L, Loughran RM, Triscott J, Arora GK, Kumar A, Tieu V, Pauli C, Reist M, Lew RJ, Houlihan SL, Fellmann C, Metallo C, Rubin MA, Emerling BM. Ravi A, et al. Among authors: lew rj. Dev Cell. 2021 Jun 7;56(11):1661-1676.e10. doi: 10.1016/j.devcel.2021.04.019. Epub 2021 May 12. Dev Cell. 2021. PMID: 33984270 Free PMC article.
ATF4 Regulates MYB to Increase γ-Globin in Response to Loss of β-Globin.
Boontanrart MY, Schröder MS, Stehli GM, Banović M, Wyman SK, Lew RJ, Bordi M, Gowen BG, DeWitt MA, Corn JE. Boontanrart MY, et al. Among authors: lew rj. Cell Rep. 2020 Aug 4;32(5):107993. doi: 10.1016/j.celrep.2020.107993. Cell Rep. 2020. PMID: 32755585 Free article.
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