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A novel uterine leiomyoma subtype exhibits NRF2 activation and mutations in genes associated with neddylation of the Cullin 3-RING E3 ligase.
Mehine M, Ahvenainen T, Khamaiseh S, Härkönen J, Reinikka S, Heikkinen T, Äyräväinen A, Pakarinen P, Härkki P, Pasanen A, Levonen AL, Bützow R, Vahteristo P. Mehine M, et al. Among authors: levonen al. Oncogenesis. 2022 Sep 7;11(1):52. doi: 10.1038/s41389-022-00425-3. Oncogenesis. 2022. PMID: 36068196 Free PMC article.
Regulation of stress signaling pathways by nitro-fatty acids.
Deen AJ, Sihvola V, Härkönen J, Patinen T, Adinolfi S, Levonen AL. Deen AJ, et al. Among authors: levonen al. Nitric Oxide. 2018 Mar 19:S1089-8603(17)30323-3. doi: 10.1016/j.niox.2018.03.012. Online ahead of print. Nitric Oxide. 2018. PMID: 29567143 Review.
Regulation of stress signaling pathways by protein lipoxidation.
Patinen T, Adinolfi S, Cortés CC, Härkönen J, Jawahar Deen A, Levonen AL. Patinen T, et al. Among authors: levonen al. Redox Biol. 2019 May;23:101114. doi: 10.1016/j.redox.2019.101114. Epub 2019 Jan 16. Redox Biol. 2019. PMID: 30709792 Free PMC article. Review.
A pan-cancer analysis shows immunoevasive characteristics in NRF2 hyperactive squamous malignancies.
Härkönen J, Pölönen P, Deen AJ, Selvarajan I, Teppo HR, Dimova EY, Kietzmann T, Ahtiainen M, Väyrynen JP, Väyrynen SA, Elomaa H, Tynkkynen N, Eklund T, Kuopio T, Talvitie EM, Taimen P, Kallajoki M, Kaikkonen MU, Heinäniemi M, Levonen AL. Härkönen J, et al. Among authors: levonen al. Redox Biol. 2023 May;61:102644. doi: 10.1016/j.redox.2023.102644. Epub 2023 Feb 27. Redox Biol. 2023. PMID: 36867945 Free PMC article.
The KEAP1-NRF2 pathway: Targets for therapy and role in cancer.
Adinolfi S, Patinen T, Jawahar Deen A, Pitkänen S, Härkönen J, Kansanen E, Küblbeck J, Levonen AL. Adinolfi S, et al. Among authors: levonen al. Redox Biol. 2023 Jul;63:102726. doi: 10.1016/j.redox.2023.102726. Epub 2023 Apr 29. Redox Biol. 2023. PMID: 37146513 Free PMC article. Review.
Oncogenic KEAP1 mutations activate TRAF2-NFκB signaling to prevent apoptosis in lung cancer cells.
Deen AJ, Adinolfi S, Härkönen J, Patinen T, Liu X, Laitinen T, Takabe P, Kainulainen K, Pasonen-Seppänen S, Gawriyski LM, Arasu UT, Selvarajan I, Mäkinen P, Laitinen H, Kansanen E, Kaikkonen MU, Poso A, Varjosalo M, Levonen AL. Deen AJ, et al. Among authors: levonen al. Redox Biol. 2024 Feb;69:103031. doi: 10.1016/j.redox.2024.103031. Epub 2024 Jan 4. Redox Biol. 2024. PMID: 38184997 Free PMC article.
Electrophilic nitro-fatty acids activate NRF2 by a KEAP1 cysteine 151-independent mechanism.
Kansanen E, Bonacci G, Schopfer FJ, Kuosmanen SM, Tong KI, Leinonen H, Woodcock SR, Yamamoto M, Carlberg C, Ylä-Herttuala S, Freeman BA, Levonen AL. Kansanen E, et al. Among authors: levonen al. J Biol Chem. 2011 Apr 22;286(16):14019-27. doi: 10.1074/jbc.M110.190710. Epub 2011 Feb 25. J Biol Chem. 2011. PMID: 21357422 Free PMC article.
Role of the Keap1-Nrf2 pathway in cancer.
Leinonen HM, Kansanen E, Pölönen P, Heinäniemi M, Levonen AL. Leinonen HM, et al. Among authors: levonen al. Adv Cancer Res. 2014;122:281-320. doi: 10.1016/B978-0-12-420117-0.00008-6. Adv Cancer Res. 2014. PMID: 24974185 Review.
Nrf2 and SQSTM1/p62 jointly contribute to mesenchymal transition and invasion in glioblastoma.
Pölönen P, Jawahar Deen A, Leinonen HM, Jyrkkänen HK, Kuosmanen S, Mononen M, Jain A, Tuomainen T, Pasonen-Seppänen S, Hartikainen JM, Mannermaa A, Nykter M, Tavi P, Johansen T, Heinäniemi M, Levonen AL. Pölönen P, et al. Among authors: levonen al. Oncogene. 2019 Dec;38(50):7473-7490. doi: 10.1038/s41388-019-0956-6. Epub 2019 Aug 23. Oncogene. 2019. PMID: 31444413
98 results