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Cross-Site Reliability of Human Induced Pluripotent stem cell-derived Cardiomyocyte Based Safety Assays Using Microelectrode Arrays: Results from a Blinded CiPA Pilot Study.
Millard D, Dang Q, Shi H, Zhang X, Strock C, Kraushaar U, Zeng H, Levesque P, Lu HR, Guillon JM, Wu JC, Li Y, Luerman G, Anson B, Guo L, Clements M, Abassi YA, Ross J, Pierson J, Gintant G. Millard D, et al. Among authors: levesque p. Toxicol Sci. 2018 Aug 1;164(2):550-562. doi: 10.1093/toxsci/kfy110. Toxicol Sci. 2018. PMID: 29718449 Free PMC article.
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[No authors listed] [No authors listed] PMID: 31963054
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[No authors listed] [No authors listed] PMID: 31962937
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[No authors listed] [No authors listed] PMID: 31963065
Time for a Fully Integrated Nonclinical-Clinical Risk Assessment to Streamline QT Prolongation Liability Determinations: A Pharma Industry Perspective.
Vargas HM, Rolf MG, Wisialowski TA, Achanzar W, Bahinski A, Bass A, Benson CT, Chaudhary KW, Couvreur N, Dota C, Engwall MJ, Michael Foley C, Gallacher D, Greiter-Wilke A, Guillon JM, Guth B, Himmel HM, Hegele-Hartung C, Ito M, Jenkinson S, Chiba K, Lagrutta A, Levesque P, Martel E, Okai Y, Peri R, Pointon A, Qu Y, Teisman A, Traebert M, Yoshinaga T, Gintant GA, Leishman DJ, Valentin JP. Vargas HM, et al. Among authors: levesque p. Clin Pharmacol Ther. 2021 Feb;109(2):310-318. doi: 10.1002/cpt.2029. Epub 2020 Sep 24. Clin Pharmacol Ther. 2021. PMID: 32866317 Free PMC article. Review.
How do the top 12 pharmaceutical companies operate safety pharmacology?
Ewart L, Gallacher DJ, Gintant G, Guillon JM, Leishman D, Levesque P, McMahon N, Mylecraine L, Sanders M, Suter W, Wallis R, Valentin JP. Ewart L, et al. Among authors: levesque p. J Pharmacol Toxicol Methods. 2012 Sep;66(2):66-70. doi: 10.1016/j.vascn.2012.03.004. Epub 2012 Apr 1. J Pharmacol Toxicol Methods. 2012. PMID: 22510338
A New Perspective in the Field of Cardiac Safety Testing through the Comprehensive In Vitro Proarrhythmia Assay Paradigm.
Fermini B, Hancox JC, Abi-Gerges N, Bridgland-Taylor M, Chaudhary KW, Colatsky T, Correll K, Crumb W, Damiano B, Erdemli G, Gintant G, Imredy J, Koerner J, Kramer J, Levesque P, Li Z, Lindqvist A, Obejero-Paz CA, Rampe D, Sawada K, Strauss DG, Vandenberg JI. Fermini B, et al. Among authors: levesque p. J Biomol Screen. 2016 Jan;21(1):1-11. doi: 10.1177/1087057115594589. Epub 2015 Jul 13. J Biomol Screen. 2016. PMID: 26170255 Review.
Assessing seizure liability using multi-electrode arrays (MEA).
Fan J, Thalody G, Kwagh J, Burnett E, Shi H, Lewen G, Chen SJ, Levesque P. Fan J, et al. Among authors: levesque p. Toxicol In Vitro. 2019 Mar;55:93-100. doi: 10.1016/j.tiv.2018.12.001. Epub 2018 Dec 4. Toxicol In Vitro. 2019. PMID: 30528373
181 results