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Applications of (19)F-NMR in Fragment-Based Drug Discovery.
Norton RS, Leung EW, Chandrashekaran IR, MacRaild CA. Norton RS, et al. Among authors: leung ew. Molecules. 2016 Jul 16;21(7):860. doi: 10.3390/molecules21070860. Molecules. 2016. PMID: 27438818 Free PMC article. Review.
Defining the interaction of perforin with calcium and the phospholipid membrane.
Traore DA, Brennan AJ, Law RH, Dogovski C, Perugini MA, Lukoyanova N, Leung EW, Norton RS, Lopez JA, Browne KA, Yagita H, Lloyd GJ, Ciccone A, Verschoor S, Trapani JA, Whisstock JC, Voskoboinik I. Traore DA, et al. Among authors: leung ew. Biochem J. 2013 Dec 15;456(3):323-35. doi: 10.1042/BJ20130999. Biochem J. 2013. PMID: 24070258
Promiscuous 2-aminothiazoles (PrATs): a frequent hitting scaffold.
Devine SM, Mulcair MD, Debono CO, Leung EW, Nissink JW, Lim SS, Chandrashekaran IR, Vazirani M, Mohanty B, Simpson JS, Baell JB, Scammells PJ, Norton RS, Scanlon MJ. Devine SM, et al. Among authors: leung ew. J Med Chem. 2015 Feb 12;58(3):1205-14. doi: 10.1021/jm501402x. Epub 2015 Jan 16. J Med Chem. 2015. PMID: 25559643
Redox-stable cyclic peptide inhibitors of the SPSB2-iNOS interaction.
Yap BK, Harjani JR, Leung EW, Nicholson SE, Scanlon MJ, Chalmers DK, Thompson PE, Baell JB, Norton RS. Yap BK, et al. Among authors: leung ew. FEBS Lett. 2016 Mar;590(6):696-704. doi: 10.1002/1873-3468.12115. Epub 2016 Mar 6. FEBS Lett. 2016. PMID: 26921848 Free article.
Design, Synthesis, and Characterization of Cyclic Peptidomimetics of the Inducible Nitric Oxide Synthase Binding Epitope That Disrupt the Protein-Protein Interaction Involving SPRY Domain-Containing Suppressor of Cytokine Signaling Box Protein (SPSB) 2 and Inducible Nitric Oxide Synthase.
Harjani JR, Yap BK, Leung EW, Lucke A, Nicholson SE, Scanlon MJ, Chalmers DK, Thompson PE, Norton RS, Baell JB. Harjani JR, et al. Among authors: leung ew. J Med Chem. 2016 Jun 23;59(12):5799-809. doi: 10.1021/acs.jmedchem.6b00386. Epub 2016 Jun 8. J Med Chem. 2016. PMID: 27214043
33 results