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Type 2 diabetes is associated with impaired jejunal enteroendocrine GLP-1 cell lineage in human obesity.
Osinski C, Le Gléau L, Poitou C, de Toro-Martin J, Genser L, Fradet M, Soula HA, Leturque A, Blugeon C, Jourdren L, Hubert EL, Clément K, Serradas P, Ribeiro A. Osinski C, et al. Among authors: leturque a. Int J Obes (Lond). 2021 Jan;45(1):170-183. doi: 10.1038/s41366-020-00694-1. Epub 2020 Oct 9. Int J Obes (Lond). 2021. PMID: 33037328 Free PMC article. Clinical Trial.
Jejunal T Cell Inflammation in Human Obesity Correlates with Decreased Enterocyte Insulin Signaling.
Monteiro-Sepulveda M, Touch S, Mendes-Sá C, André S, Poitou C, Allatif O, Cotillard A, Fohrer-Ting H, Hubert EL, Remark R, Genser L, Tordjman J, Garbin K, Osinski C, Sautès-Fridman C, Leturque A, Clément K, Brot-Laroche E. Monteiro-Sepulveda M, et al. Among authors: leturque a. Cell Metab. 2015 Jul 7;22(1):113-24. doi: 10.1016/j.cmet.2015.05.020. Epub 2015 Jun 18. Cell Metab. 2015. PMID: 26094890 Free article.
Increased jejunal permeability in human obesity is revealed by a lipid challenge and is linked to inflammation and type 2 diabetes.
Genser L, Aguanno D, Soula HA, Dong L, Trystram L, Assmann K, Salem JE, Vaillant JC, Oppert JM, Laugerette F, Michalski MC, Wind P, Rousset M, Brot-Laroche E, Leturque A, Clément K, Thenet S, Poitou C. Genser L, et al. Among authors: leturque a. J Pathol. 2018 Oct;246(2):217-230. doi: 10.1002/path.5134. Epub 2018 Aug 28. J Pathol. 2018. PMID: 29984492
AhR activation defends gut barrier integrity against damage occurring in obesity.
Postal BG, Ghezzal S, Aguanno D, André S, Garbin K, Genser L, Brot-Laroche E, Poitou C, Soula H, Leturque A, Clément K, Carrière V. Postal BG, et al. Among authors: leturque a. Mol Metab. 2020 Sep;39:101007. doi: 10.1016/j.molmet.2020.101007. Epub 2020 Apr 28. Mol Metab. 2020. PMID: 32360426 Free PMC article.
GLUT2 accumulation in enterocyte apical and intracellular membranes: a study in morbidly obese human subjects and ob/ob and high fat-fed mice.
Ait-Omar A, Monteiro-Sepulveda M, Poitou C, Le Gall M, Cotillard A, Gilet J, Garbin K, Houllier A, Château D, Lacombe A, Veyrie N, Hugol D, Tordjman J, Magnan C, Serradas P, Clément K, Leturque A, Brot-Laroche E. Ait-Omar A, et al. Among authors: leturque a. Diabetes. 2011 Oct;60(10):2598-607. doi: 10.2337/db10-1740. Epub 2011 Aug 18. Diabetes. 2011. PMID: 21852673 Free PMC article.
Short Term Palmitate Supply Impairs Intestinal Insulin Signaling via Ceramide Production.
Tran TT, Postal BG, Demignot S, Ribeiro A, Osinski C, Pais de Barros JP, Blachnio-Zabielska A, Leturque A, Rousset M, Ferré P, Hajduch E, Carrière V. Tran TT, et al. Among authors: leturque a. J Biol Chem. 2016 Jul 29;291(31):16328-38. doi: 10.1074/jbc.M115.709626. Epub 2016 Jun 2. J Biol Chem. 2016. PMID: 27255710 Free PMC article.
Mutations in SLC2A2 gene reveal hGLUT2 function in pancreatic β cell development.
Michau A, Guillemain G, Grosfeld A, Vuillaumier-Barrot S, Grand T, Keck M, L'Hoste S, Chateau D, Serradas P, Teulon J, De Lonlay P, Scharfmann R, Brot-Laroche E, Leturque A, Le Gall M. Michau A, et al. Among authors: leturque a. J Biol Chem. 2013 Oct 25;288(43):31080-92. doi: 10.1074/jbc.M113.469189. Epub 2013 Aug 28. J Biol Chem. 2013. PMID: 23986439 Free PMC article.
90 results