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Discovery, Structure-Activity Relationships, and In Vivo Activity of Dihydropyridone Agonists of the Bile Acid Receptor TGR5.
Picon S, Boulahjar R, Hoguet V, Baron M, Duplan I, Vallez E, Hennuyer N, Dumont J, Touche V, Dorchies E, Lasalle M, Descat A, Piveteau C, Biela A, Chaput L, Villoutreix BO, Lipka E, Sevin E, Culot M, Gosselet F, Lestavel S, Roussel P, Deprez-Poulain R, Leroux F, Staels B, Deprez B, Tailleux A, Charton J. Picon S, et al. Among authors: lestavel s. J Med Chem. 2023 Sep 14;66(17):11732-11760. doi: 10.1021/acs.jmedchem.2c01881. Epub 2023 Aug 28. J Med Chem. 2023. PMID: 37639383
The RXR agonist bexarotene improves cholesterol homeostasis and inhibits atherosclerosis progression in a mouse model of mixed dyslipidemia.
Lalloyer F, Fiévet C, Lestavel S, Torpier G, van der Veen J, Touche V, Bultel S, Yous S, Kuipers F, Paumelle R, Fruchart JC, Staels B, Tailleux A. Lalloyer F, et al. Among authors: lestavel s. Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2731-7. doi: 10.1161/01.ATV.0000248101.93488.84. Epub 2006 Sep 28. Arterioscler Thromb Vasc Biol. 2006. PMID: 17008586
Rexinoid bexarotene modulates triglyceride but not cholesterol metabolism via gene-specific permissivity of the RXR/LXR heterodimer in the liver.
Lalloyer F, Pedersen TA, Gross B, Lestavel S, Yous S, Vallez E, Gustafsson JA, Mandrup S, Fiévet C, Staels B, Tailleux A. Lalloyer F, et al. Among authors: lestavel s. Arterioscler Thromb Vasc Biol. 2009 Oct;29(10):1488-95. doi: 10.1161/ATVBAHA.109.189506. Epub 2009 Jul 10. Arterioscler Thromb Vasc Biol. 2009. PMID: 19592467 Free PMC article.
PPARβ/δ activation induces enteroendocrine L cell GLP-1 production.
Daoudi M, Hennuyer N, Borland MG, Touche V, Duhem C, Gross B, Caiazzo R, Kerr-Conte J, Pattou F, Peters JM, Staels B, Lestavel S. Daoudi M, et al. Among authors: lestavel s. Gastroenterology. 2011 May;140(5):1564-74. doi: 10.1053/j.gastro.2011.01.045. Epub 2011 Feb 4. Gastroenterology. 2011. PMID: 21300064 Free article.
Farnesoid X receptor deficiency improves glucose homeostasis in mouse models of obesity.
Prawitt J, Abdelkarim M, Stroeve JH, Popescu I, Duez H, Velagapudi VR, Dumont J, Bouchaert E, van Dijk TH, Lucas A, Dorchies E, Daoudi M, Lestavel S, Gonzalez FJ, Oresic M, Cariou B, Kuipers F, Caron S, Staels B. Prawitt J, et al. Among authors: lestavel s. Diabetes. 2011 Jul;60(7):1861-71. doi: 10.2337/db11-0030. Epub 2011 May 18. Diabetes. 2011. PMID: 21593203 Free PMC article.
58 results