ABCB1 (P-glycoprotein) regulates vitamin D absorption and contributes to its transintestinal efflux.
Margier M, Collet X, le May C, Desmarchelier C, André F, Lebrun C, Defoort C, Bluteau A, Borel P, Lespine A, Reboul E.
Margier M, et al. Among authors: lespine a.
FASEB J. 2019 Feb;33(2):2084-2094. doi: 10.1096/fj.201800956R. Epub 2018 Sep 17.
FASEB J. 2019.
PMID: 30222077
Docking experiments established that both D(3) and 25(OH)D(3) could bind with high affinity to Caenorhabditis elegans P-glycoprotein, used as an ABCB1 model. Finally, in a group of 39 healthy male adults, a single-nucleotide polymorphism (SNP) in ABCB1 (rs17064) was …
Docking experiments established that both D(3) and 25(OH)D(3) could bind with high affinity to Caenorhabditis elegans P-glycoprotein, used a …