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Macrophage IL-1β-positive microvesicles exhibit thrombo-inflammatory properties and are detectable in patients with active juvenile idiopathic arthritis.
Cambon A, Rebelle C, Bachelier R, Arnaud L, Robert S, Lagarde M, Muller R, Tellier E, Kara Y, Leroyer A, Farnarier C, Vallier L, Chareyre C, Retornaz K, Jurquet AL, Tran TA, Lacroix R, Dignat-George F, Kaplanski G. Cambon A, et al. Among authors: leroyer a. Front Immunol. 2023 Nov 21;14:1228122. doi: 10.3389/fimmu.2023.1228122. eCollection 2023. Front Immunol. 2023. PMID: 38077384 Free PMC article.
CD146 deficiency promotes plaque formation in a mouse model of atherosclerosis by enhancing RANTES secretion and leukocyte recruitment.
Blin MG, Bachelier R, Fallague K, Moussouni K, Aurrand-Lions M, Fernandez S, Guillet B, Robert S, Foucault-Bertaud A, Bardin N, Blot-Chabaud M, Dignat-George F, Leroyer AS. Blin MG, et al. Among authors: leroyer as. J Mol Cell Cardiol. 2019 May;130:76-87. doi: 10.1016/j.yjmcc.2019.03.017. Epub 2019 Mar 27. J Mol Cell Cardiol. 2019. PMID: 30928429
CD146 (Cluster of Differentiation 146).
Leroyer AS, Blin MG, Bachelier R, Bardin N, Blot-Chabaud M, Dignat-George F. Leroyer AS, et al. Arterioscler Thromb Vasc Biol. 2019 Jun;39(6):1026-1033. doi: 10.1161/ATVBAHA.119.312653. Arterioscler Thromb Vasc Biol. 2019. PMID: 31070478 Free article. Review.
Therapeutic targeting of soluble CD146/MCAM with the M2J-1 monoclonal antibody prevents metastasis development and procoagulant activity in CD146-positive invasive tumors.
Stalin J, Traboulsi W, Vivancos-Stalin L, Nollet M, Joshkon A, Bachelier R, Guillet B, Lacroix R, Foucault-Bertaud A, Leroyer AS, Dignat-George F, Bardin N, Blot-Chabaud M. Stalin J, et al. Among authors: leroyer as. Int J Cancer. 2020 Sep 15;147(6):1666-1679. doi: 10.1002/ijc.32909. Epub 2020 Feb 22. Int J Cancer. 2020. PMID: 32022257 Free article.
Plasmatic level of leukocyte-derived microparticles is associated with unstable plaque in asymptomatic patients with high-grade carotid stenosis.
Sarlon-Bartoli G, Bennis Y, Lacroix R, Piercecchi-Marti MD, Bartoli MA, Arnaud L, Mancini J, Boudes A, Sarlon E, Thevenin B, Leroyer AS, Squarcioni C, Magnan PE, Dignat-George F, Sabatier F. Sarlon-Bartoli G, et al. Among authors: leroyer as. J Am Coll Cardiol. 2013 Oct 15;62(16):1436-41. doi: 10.1016/j.jacc.2013.03.078. Epub 2013 May 22. J Am Coll Cardiol. 2013. PMID: 23707318 Free article.
A novel anti-CD146 antibody specifically targets cancer cells by internalizing the molecule.
Nollet M, Stalin J, Moyon A, Traboulsi W, Essaadi A, Robert S, Malissen N, Bachelier R, Daniel L, Foucault-Bertaud A, Gaudy-Marqueste C, Lacroix R, Leroyer AS, Guillet B, Bardin N, Dignat-George F, Blot-Chabaud M. Nollet M, et al. Among authors: leroyer as. Oncotarget. 2017 Nov 28;8(68):112283-112296. doi: 10.18632/oncotarget.22736. eCollection 2017 Dec 22. Oncotarget. 2017. PMID: 29348825 Free PMC article.
Multifaceted role of extracellular vesicles in atherosclerosis.
Konkoth A, Saraswat R, Dubrou C, Sabatier F, Leroyer AS, Lacroix R, Duchez AC, Dignat-George F. Konkoth A, et al. Among authors: leroyer as. Atherosclerosis. 2021 Feb;319:121-131. doi: 10.1016/j.atherosclerosis.2020.11.006. Epub 2020 Nov 11. Atherosclerosis. 2021. PMID: 33261815 Review.
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