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Downregulation of the FTO m6A RNA demethylase promotes EMT-mediated progression of epithelial tumors and sensitivity to Wnt inhibitors.
Jeschke J, Collignon E, Al Wardi C, Krayem M, Bizet M, Jia Y, Garaud S, Wimana Z, Calonne E, Hassabi B, Morandini R, Deplus R, Putmans P, Dube G, Singh NK, Koch A, Shostak K, Rizzotto L, Ross RL, Desmedt C, Bareche Y, Rothé F, Lehmann-Che J, Duterque-Coquillaud M, Leroy X, Menschaert G, Teixeira L, Guo M, Limbach PA, Close P, Chariot A, Leucci E, Ghanem G, Yuan BF, Willard-Gallo K, Sotiriou C, Marine JC, Fuks F. Jeschke J, et al. Among authors: leroy x. Nat Cancer. 2021 Jun;2(6):611-628. doi: 10.1038/s43018-021-00223-7. Epub 2021 Jun 23. Nat Cancer. 2021. PMID: 35121941 Free PMC article.
TMPRSS2:ERG gene fusion expression regulates bone markers and enhances the osteoblastic phenotype of prostate cancer bone metastases.
Delliaux C, Tian TV, Bouchet M, Fradet A, Vanpouille N, Flourens A, Deplus R, Villers A, Leroy X, Clézardin P, de Launoit Y, Bonnelye E, Duterque-Coquillaud M. Delliaux C, et al. Among authors: leroy x. Cancer Lett. 2018 Dec 1;438:32-43. doi: 10.1016/j.canlet.2018.08.027. Epub 2018 Sep 7. Cancer Lett. 2018. PMID: 30201302
TMPRSS2-ERG fusion promotes prostate cancer metastases in bone.
Deplus R, Delliaux C, Marchand N, Flourens A, Vanpouille N, Leroy X, de Launoit Y, Duterque-Coquillaud M. Deplus R, et al. Among authors: leroy x. Oncotarget. 2017 Feb 14;8(7):11827-11840. doi: 10.18632/oncotarget.14399. Oncotarget. 2017. PMID: 28055969 Free PMC article.
HIC1 (Hypermethylated in Cancer 1) modulates the contractile activity of prostate stromal fibroblasts and directly regulates CXCL12 expression.
Dubuissez M, Paget S, Abdelfettah S, Spruyt N, Dehennaut V, Boulay G, Loison I, de Schutter C, Rood BR, Duterque-Coquillaud M, Leroy X, Leprince D. Dubuissez M, et al. Among authors: leroy x. Oncotarget. 2020 Nov 10;11(45):4138-4154. doi: 10.18632/oncotarget.27786. eCollection 2020 Nov 10. Oncotarget. 2020. PMID: 33227080 Free PMC article.
MUC1 drives epithelial-mesenchymal transition in renal carcinoma through Wnt/β-catenin pathway and interaction with SNAIL promoter.
Gnemmi V, Bouillez A, Gaudelot K, Hémon B, Ringot B, Pottier N, Glowacki F, Villers A, Vindrieux D, Cauffiez C, Van Seuningen I, Bernard D, Leroy X, Aubert S, Perrais M. Gnemmi V, et al. Among authors: leroy x. Cancer Lett. 2014 May 1;346(2):225-36. doi: 10.1016/j.canlet.2013.12.029. Epub 2013 Dec 30. Cancer Lett. 2014. PMID: 24384091
Estrogen related receptor alpha in castration-resistant prostate cancer cells promotes tumor progression in bone.
Fradet A, Bouchet M, Delliaux C, Gervais M, Kan C, Benetollo C, Pantano F, Vargas G, Bouazza L, Croset M, Bala Y, Leroy X, Rosol TJ, Rieusset J, Bellahcène A, Castronovo V, Aubin JE, Clézardin P, Duterque-Coquillaud M, Bonnelye E. Fradet A, et al. Among authors: leroy x. Oncotarget. 2016 Nov 22;7(47):77071-77086. doi: 10.18632/oncotarget.12787. Oncotarget. 2016. PMID: 27776343 Free PMC article.
258 results