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Cardiac Overexpression of PDE4B Blunts β-Adrenergic Response and Maladaptive Remodeling in Heart Failure.
Karam S, Margaria JP, Bourcier A, Mika D, Varin A, Bedioune I, Lindner M, Bouadjel K, Dessillons M, Gaudin F, Lefebvre F, Mateo P, Lechène P, Gomez S, Domergue V, Robert P, Coquard C, Algalarrondo V, Samuel JL, Michel JB, Charpentier F, Ghigo A, Hirsch E, Fischmeister R, Leroy J, Vandecasteele G. Karam S, et al. Among authors: leroy j. Circulation. 2020 Jul 14;142(2):161-174. doi: 10.1161/CIRCULATIONAHA.119.042573. Epub 2020 Apr 8. Circulation. 2020. PMID: 32264695
Phosphodiesterase 4B in the cardiac L-type Ca²⁺ channel complex regulates Ca²⁺ current and protects against ventricular arrhythmias in mice.
Leroy J, Richter W, Mika D, Castro LR, Abi-Gerges A, Xie M, Scheitrum C, Lefebvre F, Schittl J, Mateo P, Westenbroek R, Catterall WA, Charpentier F, Conti M, Fischmeister R, Vandecasteele G. Leroy J, et al. J Clin Invest. 2011 Jul;121(7):2651-61. doi: 10.1172/JCI44747. Epub 2011 Jun 13. J Clin Invest. 2011. PMID: 21670503 Free PMC article.
PDEs create local domains of cAMP signaling.
Mika D, Leroy J, Vandecasteele G, Fischmeister R. Mika D, et al. Among authors: leroy j. J Mol Cell Cardiol. 2012 Feb;52(2):323-9. doi: 10.1016/j.yjmcc.2011.08.016. Epub 2011 Aug 23. J Mol Cell Cardiol. 2012. PMID: 21888909 Review.
Cyclic adenosine monophosphate phosphodiesterase type 4 protects against atrial arrhythmias.
Molina CE, Leroy J, Richter W, Xie M, Scheitrum C, Lee IO, Maack C, Rucker-Martin C, Donzeau-Gouge P, Verde I, Llach A, Hove-Madsen L, Conti M, Vandecasteele G, Fischmeister R. Molina CE, et al. Among authors: leroy j. J Am Coll Cardiol. 2012 Jun 12;59(24):2182-90. doi: 10.1016/j.jacc.2012.01.060. J Am Coll Cardiol. 2012. PMID: 22676938 Free article.
Phosphoinositide 3-kinase γ protects against catecholamine-induced ventricular arrhythmia through protein kinase A-mediated regulation of distinct phosphodiesterases.
Ghigo A, Perino A, Mehel H, Zahradníková A Jr, Morello F, Leroy J, Nikolaev VO, Damilano F, Cimino J, De Luca E, Richter W, Westenbroek R, Catterall WA, Zhang J, Yan C, Conti M, Gomez AM, Vandecasteele G, Hirsch E, Fischmeister R. Ghigo A, et al. Among authors: leroy j. Circulation. 2012 Oct 23;126(17):2073-83. doi: 10.1161/CIRCULATIONAHA.112.114074. Epub 2012 Sep 24. Circulation. 2012. PMID: 23008439 Free PMC article.
Phosphodiesterase-2 is up-regulated in human failing hearts and blunts β-adrenergic responses in cardiomyocytes.
Mehel H, Emons J, Vettel C, Wittköpper K, Seppelt D, Dewenter M, Lutz S, Sossalla S, Maier LS, Lechêne P, Leroy J, Lefebvre F, Varin A, Eschenhagen T, Nattel S, Dobrev D, Zimmermann WH, Nikolaev VO, Vandecasteele G, Fischmeister R, El-Armouche A. Mehel H, et al. Among authors: leroy j. J Am Coll Cardiol. 2013 Oct 22;62(17):1596-606. doi: 10.1016/j.jacc.2013.05.057. Epub 2013 Jun 26. J Am Coll Cardiol. 2013. PMID: 23810893 Free article.
1,232 results