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Fluorine-induced polarity increases inhibitory activity of BPTI towards chymotrypsin.
RSC Chem Biol. 2022 May 19;3(6):773-782. doi: 10.1039/d2cb00018k. eCollection 2022 Jun 8.
RSC Chem Biol. 2022.
PMID: 35755190
Free PMC article.
Approaches to Obtaining Fluorinated α-Amino Acids.
Moschner J, Stulberg V, Fernandes R, Huhmann S, Leppkes J, Koksch B.
Moschner J, et al. Among authors: leppkes j.
Chem Rev. 2019 Sep 25;119(18):10718-10801. doi: 10.1021/acs.chemrev.9b00024. Epub 2019 Aug 22.
Chem Rev. 2019.
PMID: 31436087
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Investigations from the Belly of the Beast: N-Terminally Labeled Incretin Peptides That Are Both Potent Receptor Agonists and Stable to Protease Digestion.
Berger AA, Leppkes J, Koksch B.
Berger AA, et al. Among authors: leppkes j.
ACS Cent Sci. 2021 Mar 24;7(3):400-402. doi: 10.1021/acscentsci.1c00265. Epub 2021 Mar 5.
ACS Cent Sci. 2021.
PMID: 33791422
Free PMC article.
No abstract available.
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Water Network in the Binding Pocket of Fluorinated BPTI-Trypsin Complexes─Insights from Simulation and Experiment.
Wehrhan L, Leppkes J, Dimos N, Loll B, Koksch B, Keller BG.
Wehrhan L, et al. Among authors: leppkes j.
J Phys Chem B. 2022 Dec 8;126(48):9985-9999. doi: 10.1021/acs.jpcb.2c05496. Epub 2022 Nov 21.
J Phys Chem B. 2022.
PMID: 36409613
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Competition of Nucleophilic Aromatic Substitution, σ-Bond Metathesis, and syn Hydrometalation in Titanium(III)-Catalyzed Hydrodefluorination of Arenes.
Krüger J, Leppkes J, Ehm C, Lentz D.
Krüger J, et al. Among authors: leppkes j.
Chem Asian J. 2016 Nov 7;11(21):3062-3071. doi: 10.1002/asia.201601036. Epub 2016 Sep 23.
Chem Asian J. 2016.
PMID: 27529467
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