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The Polycomb-Dependent Epigenome Controls β Cell Dysfunction, Dedifferentiation, and Diabetes.
Lu TT, Heyne S, Dror E, Casas E, Leonhardt L, Boenke T, Yang CH, Sagar, Arrigoni L, Dalgaard K, Teperino R, Enders L, Selvaraj M, Ruf M, Raja SJ, Xie H, Boenisch U, Orkin SH, Lynn FC, Hoffman BG, Grün D, Vavouri T, Lempradl AM, Pospisilik JA. Lu TT, et al. Among authors: leonhardt l. Cell Metab. 2018 Jun 5;27(6):1294-1308.e7. doi: 10.1016/j.cmet.2018.04.013. Epub 2018 May 10. Cell Metab. 2018. PMID: 29754954 Free PMC article.
Single-cell transcriptome analysis defines heterogeneity of the murine pancreatic ductal tree.
Hendley AM, Rao AA, Leonhardt L, Ashe S, Smith JA, Giacometti S, Peng XL, Jiang H, Berrios DI, Pawlak M, Li LY, Lee J, Collisson EA, Anderson MS, Fragiadakis GK, Yeh JJ, Ye CJ, Kim GE, Weaver VM, Hebrok M. Hendley AM, et al. Among authors: leonhardt l. Elife. 2021 May 19;10:e67776. doi: 10.7554/eLife.67776. Elife. 2021. PMID: 34009124 Free PMC article.
Replication confers β cell immaturity.
Puri S, Roy N, Russ HA, Leonhardt L, French EK, Roy R, Bengtsson H, Scott DK, Stewart AF, Hebrok M. Puri S, et al. Among authors: leonhardt l. Nat Commun. 2018 Feb 2;9(1):485. doi: 10.1038/s41467-018-02939-0. Nat Commun. 2018. PMID: 29396395 Free PMC article.
PDX1 dynamically regulates pancreatic ductal adenocarcinoma initiation and maintenance.
Roy N, Takeuchi KK, Ruggeri JM, Bailey P, Chang D, Li J, Leonhardt L, Puri S, Hoffman MT, Gao S, Halbrook CJ, Song Y, Ljungman M, Malik S, Wright CV, Dawson DW, Biankin AV, Hebrok M, Crawford HC. Roy N, et al. Among authors: leonhardt l. Genes Dev. 2016 Dec 15;30(24):2669-2683. doi: 10.1101/gad.291021.116. Genes Dev. 2016. PMID: 28087712 Free PMC article.
The BRG1/SOX9 axis is critical for acinar cell-derived pancreatic tumorigenesis.
Tsuda M, Fukuda A, Roy N, Hiramatsu Y, Leonhardt L, Kakiuchi N, Hoyer K, Ogawa S, Goto N, Ikuta K, Kimura Y, Matsumoto Y, Takada Y, Yoshioka T, Maruno T, Yamaga Y, Kim GE, Akiyama H, Ogawa S, Wright CV, Saur D, Takaori K, Uemoto S, Hebrok M, Chiba T, Seno H. Tsuda M, et al. Among authors: leonhardt l. J Clin Invest. 2018 Aug 1;128(8):3475-3489. doi: 10.1172/JCI94287. Epub 2018 Jul 16. J Clin Invest. 2018. PMID: 30010625 Free PMC article.
Gingival overgrowth in acute monocytic leukemia.
Leonhardt L, Harcha J, Calvo A. Leonhardt L, et al. Cleve Clin J Med. 2024 May 1;91(5):267-268. doi: 10.3949/ccjm.91a.23087. Cleve Clin J Med. 2024. PMID: 38692700 Free article. No abstract available.
KRAS degradation averts PDAC chemoresistance.
Leonhardt L, Hebrok M. Leonhardt L, et al. Nat Cancer. 2024 Mar;5(3):375-377. doi: 10.1038/s43018-023-00708-7. Nat Cancer. 2024. PMID: 38538908 No abstract available.
35 results