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Beneficial Effects of Soluble Guanylyl Cyclase Stimulation and Activation in Sickle Cell Disease Are Amplified by Hydroxyurea: In Vitro and In Vivo Studies.
Ferreira WA Jr, Chweih H, Lanaro C, Almeida CB, Brito PL, Gotardo EMF, Torres L, Miguel LI, Franco-Penteado CF, Leonardo FC, Garcia F, Saad STO, Frenette PS, Brockschnieder D, Costa FF, Stasch JP, Sandner P, Conran N. Ferreira WA Jr, et al. Among authors: leonardo fc. J Pharmacol Exp Ther. 2020 Sep;374(3):469-478. doi: 10.1124/jpet.119.264606. Epub 2020 Jul 6. J Pharmacol Exp Ther. 2020. PMID: 32631869 Free PMC article.
Reduced blood pressure in sickle cell disease is associated with decreased angiotensin converting enzyme (ACE) activity and is not modulated by ACE inhibition.
Brito PL, Dos Santos AF, Chweih H, Favero ME, Gotardo EMF, Silva JAF, Leonardo FC, Franco-Penteado CF, de Oliveira MG, Ferreira WA Jr, Zaidan BC, Billis A, Baldanzi G, Mashima DA, Antunes E, Saad STO, Costa FF, Conran N. Brito PL, et al. Among authors: leonardo fc. PLoS One. 2022 Feb 3;17(2):e0263424. doi: 10.1371/journal.pone.0263424. eCollection 2022. PLoS One. 2022. PMID: 35113975 Free PMC article.
Key endothelial cell angiogenic mechanisms are stimulated by the circulating milieu in sickle cell disease and attenuated by hydroxyurea.
Lopes FC, Traina F, Almeida CB, Leonardo FC, Franco-Penteado CF, Garrido VT, Colella MP, Soares R, Olalla-Saad ST, Costa FF, Conran N. Lopes FC, et al. Among authors: leonardo fc. Haematologica. 2015 Jun;100(6):730-9. doi: 10.3324/haematol.2014.119727. Epub 2015 Mar 13. Haematologica. 2015. PMID: 25769545 Free PMC article.
18 results