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A G1-like state allows HIV-1 to bypass SAMHD1 restriction in macrophages.
Mlcochova P, Sutherland KA, Watters SA, Bertoli C, de Bruin RA, Rehwinkel J, Neil SJ, Lenzi GM, Kim B, Khwaja A, Gage MC, Georgiou C, Chittka A, Yona S, Noursadeghi M, Towers GJ, Gupta RK. Mlcochova P, et al. EMBO J. 2017 Mar 1;36(5):604-616. doi: 10.15252/embj.201696025. Epub 2017 Jan 25. EMBO J. 2017. PMID: 28122869 Free PMC article.
p21 Restricts HIV-1 in Monocyte-Derived Dendritic Cells through the Reduction of Deoxynucleoside Triphosphate Biosynthesis and Regulation of SAMHD1 Antiviral Activity.
Valle-Casuso JC, Allouch A, David A, Lenzi GM, Studdard L, Barré-Sinoussi F, Müller-Trutwin M, Kim B, Pancino G, Sáez-Cirión A. Valle-Casuso JC, et al. Among authors: lenzi gm. J Virol. 2017 Nov 14;91(23):e01324-17. doi: 10.1128/JVI.01324-17. Print 2017 Dec 1. J Virol. 2017. PMID: 28931685 Free PMC article.
Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells.
Baldauf HM, Stegmann L, Schwarz SM, Ambiel I, Trotard M, Martin M, Burggraf M, Lenzi GM, Lejk H, Pan X, Fregoso OI, Lim ES, Abraham L, Nguyen LA, Rutsch F, König R, Kim B, Emerman M, Fackler OT, Keppler OT. Baldauf HM, et al. Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2729-2734. doi: 10.1073/pnas.1613635114. Epub 2017 Feb 22. Proc Natl Acad Sci U S A. 2017. PMID: 28228523 Free PMC article.
372 results