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Therapeutic Interleukin-6 Trans-signaling Inhibition by Olamkicept (sgp130Fc) in Patients With Active Inflammatory Bowel Disease.
Schreiber S, Aden K, Bernardes JP, Conrad C, Tran F, Höper H, Volk V, Mishra N, Blase JI, Nikolaus S, Bethge J, Kühbacher T, Röcken C, Chen M, Cottingham I, Petri N, Rasmussen BB, Lokau J, Lenk L, Garbers C, Feuerhake F, Rose-John S, Waetzig GH, Rosenstiel P. Schreiber S, et al. Among authors: lenk l. Gastroenterology. 2021 Jun;160(7):2354-2366.e11. doi: 10.1053/j.gastro.2021.02.062. Epub 2021 Mar 2. Gastroenterology. 2021. PMID: 33667488 Free article. Clinical Trial.
Targeted Microbiome Intervention by Microencapsulated Delayed-Release Niacin Beneficially Affects Insulin Sensitivity in Humans.
Fangmann D, Theismann EM, Türk K, Schulte DM, Relling I, Hartmann K, Keppler JK, Knipp JR, Rehman A, Heinsen FA, Franke A, Lenk L, Freitag-Wolf S, Appel E, Gorb S, Brenner C, Seegert D, Waetzig GH, Rosenstiel P, Schreiber S, Schwarz K, Laudes M. Fangmann D, et al. Among authors: lenk l. Diabetes Care. 2018 Mar;41(3):398-405. doi: 10.2337/dc17-1967. Epub 2017 Dec 6. Diabetes Care. 2018. PMID: 29212824
The hepatic microenvironment essentially determines tumor cell dormancy and metastatic outgrowth of pancreatic ductal adenocarcinoma.
Lenk L, Pein M, Will O, Gomez B, Viol F, Hauser C, Egberts JH, Gundlach JP, Helm O, Tiwari S, Weiskirchen R, Rose-John S, Röcken C, Mikulits W, Wenzel P, Schneider G, Saur D, Schäfer H, Sebens S. Lenk L, et al. Oncoimmunology. 2017 Oct 26;7(1):e1368603. doi: 10.1080/2162402X.2017.1368603. eCollection 2017. Oncoimmunology. 2017. PMID: 29296518 Free PMC article.
Epithelial RNase H2 Maintains Genome Integrity and Prevents Intestinal Tumorigenesis in Mice.
Aden K, Bartsch K, Dahl J, Reijns MAM, Esser D, Sheibani-Tezerji R, Sinha A, Wottawa F, Ito G, Mishra N, Knittler K, Burkholder A, Welz L, van Es J, Tran F, Lipinski S, Kakavand N, Boeger C, Lucius R, von Schoenfels W, Schafmayer C, Lenk L, Chalaris A, Clevers H, Röcken C, Kaleta C, Rose-John S, Schreiber S, Kunkel T, Rabe B, Rosenstiel P. Aden K, et al. Among authors: lenk l. Gastroenterology. 2019 Jan;156(1):145-159.e19. doi: 10.1053/j.gastro.2018.09.047. Epub 2018 Sep 28. Gastroenterology. 2019. PMID: 30273559 Free PMC article.
CD4+ T cells potently induce epithelial-mesenchymal-transition in premalignant and malignant pancreatic ductal epithelial cells-novel implications of CD4+ T cells in pancreatic cancer development.
Goebel L, Grage-Griebenow E, Gorys A, Helm O, Genrich G, Lenk L, Wesch D, Ungefroren H, Freitag-Wolf S, Sipos B, Röcken C, Schäfer H, Sebens S. Goebel L, et al. Among authors: lenk l. Oncoimmunology. 2015 Jan 22;4(4):e1000083. doi: 10.1080/2162402X.2014.1000083. eCollection 2015 Apr. Oncoimmunology. 2015. PMID: 26137395 Free PMC article.
The anti-oxidative transcription factor Nuclear factor E2 related factor-2 (Nrf2) counteracts TGF-β1 mediated growth inhibition of pancreatic ductal epithelial cells -Nrf2 as determinant of pro-tumorigenic functions of TGF-β1.
Genrich G, Kruppa M, Lenk L, Helm O, Broich A, Freitag-Wolf S, Röcken C, Sipos B, Schäfer H, Sebens S. Genrich G, et al. Among authors: lenk l. BMC Cancer. 2016 Feb 25;16:155. doi: 10.1186/s12885-016-2191-7. BMC Cancer. 2016. PMID: 26915435 Free PMC article.
Hypothalamic Inflammation in Human Obesity Is Mediated by Environmental and Genetic Factors.
Kreutzer C, Peters S, Schulte DM, Fangmann D, Türk K, Wolff S, van Eimeren T, Ahrens M, Beckmann J, Schafmayer C, Becker T, Kerby T, Rohr A, Riedel C, Heinsen FA, Degenhardt F, Franke A, Rosenstiel P, Zubek N, Henning C, Freitag-Wolf S, Dempfle A, Psilopanagioti A, Petrou-Papadaki H, Lenk L, Jansen O, Schreiber S, Laudes M. Kreutzer C, et al. Among authors: lenk l. Diabetes. 2017 Sep;66(9):2407-2415. doi: 10.2337/db17-0067. Epub 2017 Jun 2. Diabetes. 2017. PMID: 28576837
Synergism between IL7R and CXCR4 drives BCR-ABL induced transformation in Philadelphia chromosome-positive acute lymphoblastic leukemia.
Abdelrasoul H, Vadakumchery A, Werner M, Lenk L, Khadour A, Young M, El Ayoubi O, Vogiatzi F, Krämer M, Schmid V, Chen Z, Yousafzai Y, Cario G, Schrappe M, Müschen M, Halsey C, Mulaw MA, Schewe DM, Hobeika E, Alsadeq A, Jumaa H. Abdelrasoul H, et al. Among authors: lenk l. Nat Commun. 2020 Jun 24;11(1):3194. doi: 10.1038/s41467-020-16927-w. Nat Commun. 2020. PMID: 32581241 Free PMC article.
In vivo inducible reverse genetics in patients' tumors to identify individual therapeutic targets.
Carlet M, Völse K, Vergalli J, Becker M, Herold T, Arner A, Senft D, Jurinovic V, Liu WH, Gao Y, Dill V, Fehse B, Baldus CD, Bastian L, Lenk L, Schewe DM, Bagnoli JW, Vick B, Schmid JP, Wilhelm A, Marschalek R, Jost PJ, Miething C, Riecken K, Schmidt-Supprian M, Binder V, Jeremias I. Carlet M, et al. Among authors: lenk l. Nat Commun. 2021 Sep 27;12(1):5655. doi: 10.1038/s41467-021-25963-z. Nat Commun. 2021. PMID: 34580292 Free PMC article.
34 results