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Fluorinated indole-imidazole conjugates: Selective orally bioavailable 5-HT7 receptor low-basicity agonists, potential neuropathic painkillers.
Hogendorf AS, Hogendorf A, Popiołek-Barczyk K, Ciechanowska A, Mika J, Satała G, Walczak M, Latacz G, Handzlik J, Kieć-Kononowicz K, Ponimaskin E, Schade S, Zeug A, Bijata M, Kubicki M, Kurczab R, Lenda T, Staroń J, Bugno R, Duszyńska B, Pilarski B, Bojarski AJ. Hogendorf AS, et al. Among authors: lenda t. Eur J Med Chem. 2019 May 15;170:261-275. doi: 10.1016/j.ejmech.2019.03.017. Epub 2019 Mar 11. Eur J Med Chem. 2019. PMID: 30904783
The influence of modifications in imide fragment structure on 5-HT(1A) and 5-HT(7) receptor affinity and in vivo pharmacological properties of some new 1-(m-trifluoromethylphenyl)piperazines.
Paluchowska MH, Bugno R, Duszyńska B, Tatarczyńska E, Nikiforuk A, Lenda T, Chojnacka-Wójcik E. Paluchowska MH, et al. Among authors: lenda t. Bioorg Med Chem. 2007 Nov 15;15(22):7116-25. doi: 10.1016/j.bmc.2007.07.029. Epub 2007 Aug 22. Bioorg Med Chem. 2007. PMID: 17825569
Antidepressant and antipsychotic activity of new quinoline- and isoquinoline-sulfonamide analogs of aripiprazole targeting serotonin 5-HT₁A/5-HT₂A/5-HT₇ and dopamine D₂/D₃ receptors.
Zajdel P, Marciniec K, Maślankiewicz A, Grychowska K, Satała G, Duszyńska B, Lenda T, Siwek A, Nowak G, Partyka A, Wróbel D, Jastrzębska-Więsek M, Bojarski AJ, Wesołowska A, Pawłowski M. Zajdel P, et al. Among authors: lenda t. Eur J Med Chem. 2013 Feb;60:42-50. doi: 10.1016/j.ejmech.2012.11.042. Epub 2012 Dec 5. Eur J Med Chem. 2013. PMID: 23279866
Towards new 5-HT7 antagonists among arylsulfonamide derivatives of (aryloxy)ethyl-alkyl amines: Multiobjective based design, synthesis, and antidepressant and anxiolytic properties.
Canale V, Kurczab R, Partyka A, Satała G, Lenda T, Jastrzębska-Więsek M, Wesołowska A, Bojarski AJ, Zajdel P. Canale V, et al. Among authors: lenda t. Eur J Med Chem. 2016 Jan 27;108:334-346. doi: 10.1016/j.ejmech.2015.11.040. Epub 2015 Nov 30. Eur J Med Chem. 2016. PMID: 26698537
Allosteric Inhibition of Serotonin 5-HT7 Receptors by Zinc Ions.
Satała G, Duszyńska B, Lenda T, Nowak G, Bojarski AJ. Satała G, et al. Among authors: lenda t. Mol Neurobiol. 2018 Apr;55(4):2897-2910. doi: 10.1007/s12035-017-0536-0. Epub 2017 Apr 28. Mol Neurobiol. 2018. PMID: 28455702 Free PMC article.
Novel multi-target azinesulfonamides of cyclic amine derivatives as potential antipsychotics with pro-social and pro-cognitive effects.
Zajdel P, Kos T, Marciniec K, Satała G, Canale V, Kamiński K, Hołuj M, Lenda T, Koralewski R, Bednarski M, Nowiński L, Wójcikowski J, Daniel WA, Nikiforuk A, Nalepa I, Chmielarz P, Kuśmierczyk J, Bojarski AJ, Popik P. Zajdel P, et al. Among authors: lenda t. Eur J Med Chem. 2018 Feb 10;145:790-804. doi: 10.1016/j.ejmech.2018.01.002. Epub 2018 Jan 3. Eur J Med Chem. 2018. PMID: 29407591
2-Aminoimidazole-based antagonists of the 5-HT6 receptor - A new concept in aminergic GPCR ligand design.
Hogendorf AS, Hogendorf A, Kurczab R, Kalinowska-Tłuścik J, Popik P, Nikiforuk A, Krawczyk M, Satała G, Lenda T, Knutelska J, Bugno R, Staroń J, Pietruś W, Matłoka M, Dubiel K, Moszczyński-Pętkowski R, Pieczykolan J, Wieczorek M, Pilarski B, Zajdel P, Bojarski AJ. Hogendorf AS, et al. Among authors: lenda t. Eur J Med Chem. 2019 Oct 1;179:1-15. doi: 10.1016/j.ejmech.2019.06.001. Epub 2019 Jun 5. Eur J Med Chem. 2019. PMID: 31229883
Virtual screening-driven discovery of dual 5-HT6/5-HT2A receptor ligands with pro-cognitive properties.
Staroń J, Kurczab R, Warszycki D, Satała G, Krawczyk M, Bugno R, Lenda T, Popik P, Hogendorf AS, Hogendorf A, Dubiel K, Matłoka M, Moszczyński-Pętkowski R, Pieczykolan J, Wieczorek M, Zajdel P, Bojarski AJ. Staroń J, et al. Among authors: lenda t. Eur J Med Chem. 2020 Jan 1;185:111857. doi: 10.1016/j.ejmech.2019.111857. Epub 2019 Nov 7. Eur J Med Chem. 2020. PMID: 31734022 Free article.
42 results