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Targeting Insulin-Degrading Enzyme in Insulin Clearance.
Leissring MA, González-Casimiro CM, Merino B, Suire CN, Perdomo G. Leissring MA, et al. Int J Mol Sci. 2021 Feb 24;22(5):2235. doi: 10.3390/ijms22052235. Int J Mol Sci. 2021. PMID: 33668109 Free PMC article. Review.
Molecular basis for the thiol sensitivity of insulin-degrading enzyme.
Neant-Fery M, Garcia-Ordoñez RD, Logan TP, Selkoe DJ, Li L, Reinstatler L, Leissring MA. Neant-Fery M, et al. Among authors: leissring ma. Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9582-7. doi: 10.1073/pnas.0801261105. Epub 2008 Jul 8. Proc Natl Acad Sci U S A. 2008. PMID: 18621727 Free PMC article.
Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin.
Leissring MA, Malito E, Hedouin S, Reinstatler L, Sahara T, Abdul-Hay SO, Choudhry S, Maharvi GM, Fauq AH, Huzarska M, May PS, Choi S, Logan TP, Turk BE, Cantley LC, Manolopoulou M, Tang WJ, Stein RL, Cuny GD, Selkoe DJ. Leissring MA, et al. PLoS One. 2010 May 7;5(5):e10504. doi: 10.1371/journal.pone.0010504. PLoS One. 2010. PMID: 20498699 Free PMC article.
Selective Targeting of Extracellular Insulin-Degrading Enzyme by Quasi-Irreversible Thiol-Modifying Inhibitors.
Abdul-Hay SO, Bannister TD, Wang H, Cameron MD, Caulfield TR, Masson A, Bertrand J, Howard EA, McGuire MP, Crisafulli U, Rosenberry TR, Topper CL, Thompson CR, Schürer SC, Madoux F, Hodder P, Leissring MA. Abdul-Hay SO, et al. Among authors: leissring ma. ACS Chem Biol. 2015 Dec 18;10(12):2716-24. doi: 10.1021/acschembio.5b00334. Epub 2015 Sep 30. ACS Chem Biol. 2015. PMID: 26398879 Free PMC article.
66 results