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PSGL-1 attenuates early TCR signaling to suppress CD8+ T cell progenitor differentiation and elicit terminal CD8+ T cell exhaustion.
Hope JL, Otero DC, Bae EA, Stairiker CJ, Palete AB, Faso HA, Lin M, Henriquez ML, Roy S, Seo H, Lei X, Wang ES, Chow S, Tinoco R, Daniels GA, Yip K, Campos AR, Yin J, Adams PD, Rao A, Bradley LM. Hope JL, et al. Among authors: lei x. Cell Rep. 2023 May 30;42(5):112436. doi: 10.1016/j.celrep.2023.112436. Epub 2023 Apr 26. Cell Rep. 2023. PMID: 37115668 Free PMC article.
Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence.
Vizioli MG, Liu T, Miller KN, Robertson NA, Gilroy K, Lagnado AB, Perez-Garcia A, Kiourtis C, Dasgupta N, Lei X, Kruger PJ, Nixon C, Clark W, Jurk D, Bird TG, Passos JF, Berger SL, Dou Z, Adams PD. Vizioli MG, et al. Among authors: lei x. Genes Dev. 2020 Mar 1;34(5-6):428-445. doi: 10.1101/gad.331272.119. Epub 2020 Jan 30. Genes Dev. 2020. PMID: 32001510 Free PMC article.
A JAK/STAT-mediated inflammatory signaling cascade drives oncogenesis in AF10-rearranged AML.
Chen BR, Deshpande A, Barbosa K, Kleppe M, Lei X, Yeddula N, Vela PS, Campos AR, Wechsler-Reya RJ, Bagchi A, Meshinchi S, Eaves C, Jeremias I, Haferlach T, Frank DA, Ronai Z, Chanda S, Armstrong SA, Adams PD, Levine RL, Deshpande AJ. Chen BR, et al. Among authors: lei x. Blood. 2021 Jun 17;137(24):3403-3415. doi: 10.1182/blood.2020009023. Blood. 2021. PMID: 33690798 Free PMC article.
Transcriptional control of leukemogenesis by the chromatin reader SGF29.
Barbosa K, Deshpande A, Perales M, Xiang P, Murad R, Pramod AB, Minkina A, Robertson N, Schischlik F, Lei X, Sun Y, Brown A, Amend D, Jeremias I, Doench JG, Humphries RK, Ruppin E, Shendure J, Mali P, Adams PD, Deshpande AJ. Barbosa K, et al. Among authors: lei x. Blood. 2024 Feb 22;143(8):697-712. doi: 10.1182/blood.2023021234. Blood. 2024. PMID: 38048593
BRD4-mediated repression of p53 is a target for combination therapy in AML.
Latif AL, Newcombe A, Li S, Gilroy K, Robertson NA, Lei X, Stewart HJS, Cole J, Terradas MT, Rishi L, McGarry L, McKeeve C, Reid C, Clark W, Campos J, Kirschner K, Davis A, Lopez J, Sakamaki JI, Morton JP, Ryan KM, Tait SWG, Abraham SA, Holyoake T, Higgins B, Huang X, Blyth K, Copland M, Chevassut TJT, Keeshan K, Adams PD. Latif AL, et al. Among authors: lei x. Nat Commun. 2021 Jan 11;12(1):241. doi: 10.1038/s41467-020-20378-8. Nat Commun. 2021. PMID: 33431824 Free PMC article.
Apoptotic stress causes mtDNA release during senescence and drives the SASP.
Victorelli S, Salmonowicz H, Chapman J, Martini H, Vizioli MG, Riley JS, Cloix C, Hall-Younger E, Machado Espindola-Netto J, Jurk D, Lagnado AB, Sales Gomez L, Farr JN, Saul D, Reed R, Kelly G, Eppard M, Greaves LC, Dou Z, Pirius N, Szczepanowska K, Porritt RA, Huang H, Huang TY, Mann DA, Masuda CA, Khosla S, Dai H, Kaufmann SH, Zacharioudakis E, Gavathiotis E, LeBrasseur NK, Lei X, Sainz AG, Korolchuk VI, Adams PD, Shadel GS, Tait SWG, Passos JF. Victorelli S, et al. Among authors: lei x. Nature. 2023 Oct;622(7983):627-636. doi: 10.1038/s41586-023-06621-4. Epub 2023 Oct 11. Nature. 2023. PMID: 37821702 Free PMC article.
Author Correction: Apoptotic stress causes mtDNA release during senescence and drives the SASP.
Victorelli S, Salmonowicz H, Chapman J, Martini H, Vizioli MG, Riley JS, Cloix C, Hall-Younger E, Machado Espindola-Netto J, Jurk D, Lagnado AB, Sales Gomez L, Farr JN, Saul D, Reed R, Kelly G, Eppard M, Greaves LC, Dou Z, Pirius N, Szczepanowska K, Porritt RA, Huang H, Huang TY, Mann DA, Masuda CA, Khosla S, Dai H, Kaufmann SH, Zacharioudakis E, Gavathiotis E, LeBrasseur NK, Lei X, Sainz AG, Korolchuk VI, Adams PD, Shadel GS, Tait SWG, Passos JF. Victorelli S, et al. Among authors: lei x. Nature. 2024 Jan;625(7995):E15. doi: 10.1038/s41586-023-07002-7. Nature. 2024. PMID: 38168624 Free PMC article. No abstract available.
A mitochondria-regulated p53-CCF circuit integrates genome integrity with inflammation.
Miller KN, Li B, Pierce-Hoffman HR, Lei X, Havas AP, Patel S, Macip CC, Victorelli SG, Woo SH, Lagnado AB, Liu T, Dasgupta N, Lyu J, Altman Y, Porritt RA, Garcia G, Mogler C, Dou Z, Chen C, Passos JF, Adams PD. Miller KN, et al. Among authors: lei x. bioRxiv [Preprint]. 2023 Nov 21:2023.11.20.567963. doi: 10.1101/2023.11.20.567963. bioRxiv. 2023. PMID: 38045344 Free PMC article. Preprint.
4,453 results