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Dysfunction of Cellular Proteostasis in Parkinson's Disease.
Lehtonen Š, Sonninen TM, Wojciechowski S, Goldsteins G, Koistinaho J. Lehtonen Š, et al. Front Neurosci. 2019 May 10;13:457. doi: 10.3389/fnins.2019.00457. eCollection 2019. Front Neurosci. 2019. PMID: 31133790 Free PMC article. Review.
Metabolic alterations in Parkinson's disease astrocytes.
Sonninen TM, Hämäläinen RH, Koskuvi M, Oksanen M, Shakirzyanova A, Wojciechowski S, Puttonen K, Naumenko N, Goldsteins G, Laham-Karam N, Lehtonen M, Tavi P, Koistinaho J, Lehtonen Š. Sonninen TM, et al. Among authors: lehtonen s, lehtonen m. Sci Rep. 2020 Sep 2;10(1):14474. doi: 10.1038/s41598-020-71329-8. Sci Rep. 2020. PMID: 32879386 Free PMC article.
Generation of a human induced pluripotent stem cell line (UEFi003-A) carrying heterozygous A673T variant in amyloid precursor protein associated with a reduced risk of Alzheimer's disease.
Rolova T, Wu YC, Koskuvi M, Voutilainen J, Sonninen TM, Kuusisto J, Laakso M, Hämäläinen RH, Koistinaho J, Lehtonen Š. Rolova T, et al. Among authors: lehtonen s. Stem Cell Res. 2020 Oct;48:101968. doi: 10.1016/j.scr.2020.101968. Epub 2020 Sep 2. Stem Cell Res. 2020. PMID: 32911327 Free article.
CNS Redox Homeostasis and Dysfunction in Neurodegenerative Diseases.
Goldsteins G, Hakosalo V, Jaronen M, Keuters MH, Lehtonen Š, Koistinaho J. Goldsteins G, et al. Among authors: lehtonen s. Antioxidants (Basel). 2022 Feb 16;11(2):405. doi: 10.3390/antiox11020405. Antioxidants (Basel). 2022. PMID: 35204286 Free PMC article. Review.
Human iPSC-derived microglia carrying the LRRK2-G2019S mutation show a Parkinson's disease related transcriptional profile and function.
Ohtonen S, Giudice L, Jäntti H, Fazaludeen MF, Shakirzyanova A, Gómez-Budia M, Välimäki NN, Niskanen J, Korvenlaita N, Fagerlund I, Koistinaho J, Amiry-Moghaddam M, Savchenko E, Roybon L, Lehtonen Š, Korhonen P, Malm T. Ohtonen S, et al. Among authors: lehtonen s. Sci Rep. 2023 Dec 13;13(1):22118. doi: 10.1038/s41598-023-49294-9. Sci Rep. 2023. PMID: 38092815 Free PMC article.
221 results