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Distinct contributions of metabolic dysfunction and genetic risk factors in the pathogenesis of non-alcoholic fatty liver disease.
Luukkonen PK, Qadri S, Ahlholm N, Porthan K, Männistö V, Sammalkorpi H, Penttilä AK, Hakkarainen A, Lehtimäki TE, Gaggini M, Gastaldelli A, Ala-Korpela M, Orho-Melander M, Arola J, Juuti A, Pihlajamäki J, Hodson L, Yki-Järvinen H. Luukkonen PK, et al. Among authors: lehtimaki te. J Hepatol. 2022 Mar;76(3):526-535. doi: 10.1016/j.jhep.2021.10.013. Epub 2021 Oct 25. J Hepatol. 2022. PMID: 34710482 Free PMC article.
Effect of a ketogenic diet on hepatic steatosis and hepatic mitochondrial metabolism in nonalcoholic fatty liver disease.
Luukkonen PK, Dufour S, Lyu K, Zhang XM, Hakkarainen A, Lehtimäki TE, Cline GW, Petersen KF, Shulman GI, Yki-Järvinen H. Luukkonen PK, et al. Among authors: lehtimaki te. Proc Natl Acad Sci U S A. 2020 Mar 31;117(13):7347-7354. doi: 10.1073/pnas.1922344117. Epub 2020 Mar 16. Proc Natl Acad Sci U S A. 2020. PMID: 32179679 Free PMC article.
The PNPLA3-I148M variant increases polyunsaturated triglycerides in human adipose tissue.
Qadri S, Lallukka-Brück S, Luukkonen PK, Zhou Y, Gastaldelli A, Orho-Melander M, Sammalkorpi H, Juuti A, Penttilä AK, Perttilä J, Hakkarainen A, Lehtimäki TE, Orešič M, Hyötyläinen T, Hodson L, Olkkonen VM, Yki-Järvinen H. Qadri S, et al. Among authors: lehtimaki te. Liver Int. 2020 Sep;40(9):2128-2138. doi: 10.1111/liv.14507. Epub 2020 May 18. Liver Int. 2020. PMID: 32386450
The PNPLA3 I148M variant increases ketogenesis and decreases hepatic de novo lipogenesis and mitochondrial function in humans.
Luukkonen PK, Porthan K, Ahlholm N, Rosqvist F, Dufour S, Zhang XM, Lehtimäki TE, Seppänen W, Orho-Melander M, Hodson L, Petersen KF, Shulman GI, Yki-Järvinen H. Luukkonen PK, et al. Among authors: lehtimaki te. Cell Metab. 2023 Nov 7;35(11):1887-1896.e5. doi: 10.1016/j.cmet.2023.10.008. Epub 2023 Oct 30. Cell Metab. 2023. PMID: 37909034 Free article.
Marked difference in liver fat measured by histology vs. magnetic resonance-proton density fat fraction: A meta-analysis.
Qadri S, Vartiainen E, Lahelma M, Porthan K, Tang A, Idilman IS, Runge JH, Juuti A, Penttilä AK, Dabek J, Lehtimäki TE, Seppänen W, Arola J, Arkkila P, Stoker J, Karcaaltincaba M, Pavlides M, Loomba R, Sirlin CB, Tukiainen T, Yki-Järvinen H. Qadri S, et al. Among authors: lehtimaki te. JHEP Rep. 2023 Oct 11;6(1):100928. doi: 10.1016/j.jhepr.2023.100928. eCollection 2024 Jan. JHEP Rep. 2023. PMID: 38089550 Free PMC article.
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