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The Tankyrase Inhibitor OM-153 Demonstrates Antitumor Efficacy and a Therapeutic Window in Mouse Models.
Brinch SA, Amundsen-Isaksen E, Espada S, Hammarström C, Aizenshtadt A, Olsen PA, Holmen L, Høyem M, Scholz H, Grødeland G, Sowa ST, Galera-Prat A, Lehtiö L, Meerts IATM, Leenders RGG, Wegert A, Krauss S, Waaler J. Brinch SA, et al. Among authors: lehtio l. Cancer Res Commun. 2022 Apr 20;2(4):233-245. doi: 10.1158/2767-9764.CRC-22-0027. eCollection 2022 Apr. Cancer Res Commun. 2022. PMID: 36873622 Free PMC article.
Structure of Escherichia coli pyruvate formate-lyase with pyruvate.
Lehtiö L, Leppänen VM, Kozarich JW, Goldman A. Lehtiö L, et al. Acta Crystallogr D Biol Crystallogr. 2002 Dec;58(Pt 12):2209-12. doi: 10.1107/s0907444902016402. Epub 2002 Nov 23. Acta Crystallogr D Biol Crystallogr. 2002. PMID: 12454503
Structural basis for regulation of the human acetyl-CoA thioesterase 12 and interactions with the steroidogenic acute regulatory protein-related lipid transfer (START) domain.
Swarbrick CM, Roman N, Cowieson N, Patterson EI, Nanson J, Siponen MI, Berglund H, Lehtiö L, Forwood JK. Swarbrick CM, et al. Among authors: lehtio l. J Biol Chem. 2014 Aug 29;289(35):24263-74. doi: 10.1074/jbc.M114.589408. Epub 2014 Jul 7. J Biol Chem. 2014. PMID: 25002576 Free PMC article.
Structural studies of tri-functional human GART.
Welin M, Grossmann JG, Flodin S, Nyman T, Stenmark P, Trésaugues L, Kotenyova T, Johansson I, Nordlund P, Lehtiö L. Welin M, et al. Among authors: lehtio l. Nucleic Acids Res. 2010 Nov;38(20):7308-19. doi: 10.1093/nar/gkq595. Epub 2010 Jul 14. Nucleic Acids Res. 2010. PMID: 20631005 Free PMC article.
The DEXD/H-box RNA helicase DDX19 is regulated by an {alpha}-helical switch.
Collins R, Karlberg T, Lehtiö L, Schütz P, van den Berg S, Dahlgren LG, Hammarström M, Weigelt J, Schüler H. Collins R, et al. Among authors: lehtio l. J Biol Chem. 2009 Apr 17;284(16):10296-300. doi: 10.1074/jbc.C900018200. Epub 2009 Feb 25. J Biol Chem. 2009. PMID: 19244245 Free PMC article.
99 results