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EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology.
Brennecke P, Rasina D, Aubi O, Herzog K, Landskron J, Cautain B, Vicente F, Quintana J, Mestres J, Stechmann B, Ellinger B, Brea J, Kolanowski JL, Pilarski R, Orzaez M, Pineda-Lucena A, Laraia L, Nami F, Zielenkiewicz P, Paruch K, Hansen E, von Kries JP, Neuenschwander M, Specker E, Bartunek P, Simova S, Leśnikowski Z, Krauss S, Lehtiö L, Bilitewski U, Brönstrup M, Taskén K, Jirgensons A, Lickert H, Clausen MH, Andersen JH, Vicent MJ, Genilloud O, Martinez A, Nazaré M, Fecke W, Gribbon P. Brennecke P, et al. Among authors: lehtio l. SLAS Discov. 2019 Mar;24(3):398-413. doi: 10.1177/2472555218816276. Epub 2019 Jan 7. SLAS Discov. 2019. PMID: 30616481 Free PMC article.
Oligomerisation mediated by the D2 domain of DTX3L is critical for DTX3L-PARP9 reading function of mono-ADP-ribosylated androgen receptor.
Vela-Rodríguez C, Yang C, Alanen HI, Eki R, Abbas TA, Maksimainen MM, Glumoff T, Duman R, Wagner A, Paschal BM, Lehtiö L. Vela-Rodríguez C, et al. Among authors: lehtio l. bioRxiv [Preprint]. 2023 Nov 29:2023.11.29.569193. doi: 10.1101/2023.11.29.569193. bioRxiv. 2023. PMID: 38076829 Free PMC article. Updated. Preprint.
Design, Synthesis and Evaluation of Inhibitors of the SARS-CoV2 nsp3 Macrodomain.
Sherrill LM, Joya EE, Walker A, Roy A, Alhammad YM, Atobatele M, Wazir S, Abbas G, Keane P, Zhuo J, Leung AKL, Johnson DK, Lehtiö L, Fehr AR, Ferraris D. Sherrill LM, et al. Among authors: lehtio l. bioRxiv [Preprint]. 2022 Feb 28:2022.02.27.482176. doi: 10.1101/2022.02.27.482176. bioRxiv. 2022. PMID: 35262078 Free PMC article. Updated. Preprint.
Tankyrases as drug targets.
Lehtiö L, Chi NW, Krauss S. Lehtiö L, et al. FEBS J. 2013 Aug;280(15):3576-93. doi: 10.1111/febs.12320. Epub 2013 Jun 18. FEBS J. 2013. PMID: 23648170 Free article. Review.
Development and structural analysis of adenosine site binding tankyrase inhibitors.
Haikarainen T, Waaler J, Ignatev A, Nkizinkiko Y, Venkannagari H, Obaji E, Krauss S, Lehtiö L. Haikarainen T, et al. Among authors: lehtio l. Bioorg Med Chem Lett. 2016 Jan 15;26(2):328-333. doi: 10.1016/j.bmcl.2015.12.018. Epub 2015 Dec 8. Bioorg Med Chem Lett. 2016. PMID: 26706174 Free article.
Discovery of a Novel Series of Tankyrase Inhibitors by a Hybridization Approach.
Anumala UR, Waaler J, Nkizinkiko Y, Ignatev A, Lazarow K, Lindemann P, Olsen PA, Murthy S, Obaji E, Majouga AG, Leonov S, von Kries JP, Lehtiö L, Krauss S, Nazaré M. Anumala UR, et al. Among authors: lehtio l. J Med Chem. 2017 Dec 28;60(24):10013-10025. doi: 10.1021/acs.jmedchem.7b00883. Epub 2017 Dec 8. J Med Chem. 2017. PMID: 29155568
Preclinical Lead Optimization of a 1,2,4-Triazole Based Tankyrase Inhibitor.
Waaler J, Leenders RGG, Sowa ST, Alam Brinch S, Lycke M, Nieczypor P, Aertssen S, Murthy S, Galera-Prat A, Damen E, Wegert A, Nazaré M, Lehtiö L, Krauss S. Waaler J, et al. Among authors: lehtio l. J Med Chem. 2020 Jul 9;63(13):6834-6846. doi: 10.1021/acs.jmedchem.0c00208. Epub 2020 Jun 23. J Med Chem. 2020. PMID: 32511917 Free PMC article.
Activity-Based Screening Assay for Mono-ADP-Ribosylhydrolases.
Wazir S, Maksimainen MM, Alanen HI, Galera-Prat A, Lehtiö L. Wazir S, et al. Among authors: lehtio l. SLAS Discov. 2021 Jan;26(1):67-76. doi: 10.1177/2472555220928911. Epub 2020 Jun 12. SLAS Discov. 2021. PMID: 32527186 Free article.
99 results