Lehr T - Search Results

1

Data Digitizing: Accurate and Precise Data Extraction for Quantitative Systems Pharmacology and Physiologically-Based Pharmacokinetic Modeling.

Wojtyniak JG, Britz H, Selzer D, Schwab M, Lehr T. Wojtyniak JG, et al. Among authors: lehr t. CPT Pharmacometrics Syst Pharmacol. 2020 Jun;9(6):322-331. doi: 10.1002/psp4.12511. Epub 2020 Jun 16. CPT Pharmacometrics Syst Pharmacol. 2020. PMID: 32543786 Free PMC article. Review.

2

Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration.

Wilman HR, Parisinos CA, Atabaki-Pasdar N, Kelly M, Thomas EL, Neubauer S; IMI DIRECT Consortium; Mahajan A, Hingorani AD, Patel RS, Hemingway H, Franks PW, Bell JD, Banerjee R, Yaghootkar H. Wilman HR, et al. J Hepatol. 2019 Sep;71(3):594-602. doi: 10.1016/j.jhep.2019.05.032. Epub 2019 Jun 19. J Hepatol. 2019. PMID: 31226389 Free PMC article.

3

Problematic Internet Use among Adolescents 18 Months after the Onset of the COVID-19 Pandemic.

Paulus FW, Joas J, Gerstner I, Kühn A, Wenning M, Gehrke T, Burckhart H, Richter U, Nonnenmacher A, Zemlin M, Lücke T, Brinkmann F, Rothoeft T, Lehr T, Möhler E. Paulus FW, et al. Among authors: lehr t. Children (Basel). 2022 Nov 10;9(11):1724. doi: 10.3390/children9111724. Children (Basel). 2022. PMID: 36360452 Free PMC article.

4

Pharmacokinetics of (synthetic) cannabinoids in pigs and their relevance for clinical and forensic toxicology.

Schaefer N, Wojtyniak JG, Kettner M, Schlote J, Laschke MW, Ewald AH, Lehr T, Menger MD, Maurer HH, Schmidt PH. Schaefer N, et al. Among authors: lehr t. Toxicol Lett. 2016 Jun 24;253:7-16. doi: 10.1016/j.toxlet.2016.04.021. Epub 2016 Apr 23. Toxicol Lett. 2016. PMID: 27113702

5

Treatment of chronic hepatitis D with the entry inhibitor myrcludex B: First results of a phase Ib/IIa study.

Bogomolov P, Alexandrov A, Voronkova N, Macievich M, Kokina K, Petrachenkova M, Lehr T, Lempp FA, Wedemeyer H, Haag M, Schwab M, Haefeli WE, Blank A, Urban S. Bogomolov P, et al. Among authors: lehr t. J Hepatol. 2016 Sep;65(3):490-8. doi: 10.1016/j.jhep.2016.04.016. Epub 2016 Apr 27. J Hepatol. 2016. PMID: 27132170 Clinical Trial.

6

First-in-human application of the novel hepatitis B and hepatitis D virus entry inhibitor myrcludex B.

Blank A, Markert C, Hohmann N, Carls A, Mikus G, Lehr T, Alexandrov A, Haag M, Schwab M, Urban S, Haefeli WE. Blank A, et al. Among authors: lehr t. J Hepatol. 2016 Sep;65(3):483-9. doi: 10.1016/j.jhep.2016.04.013. Epub 2016 Apr 27. J Hepatol. 2016. PMID: 27132172

7

Clarithromycin, Midazolam, and Digoxin: Application of PBPK Modeling to Gain New Insights into Drug-Drug Interactions and Co-medication Regimens.

Moj D, Hanke N, Britz H, Frechen S, Kanacher T, Wendl T, Haefeli WE, Lehr T. Moj D, et al. Among authors: lehr t. AAPS J. 2017 Jan;19(1):298-312. doi: 10.1208/s12248-016-0009-9. Epub 2016 Nov 7. AAPS J. 2017. PMID: 27822600

8

A physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model of the histone deacetylase (HDAC) inhibitor vorinostat for pediatric and adult patients and its application for dose specification.

Moj D, Britz H, Burhenne J, Stewart CF, Egerer G, Haefeli WE, Lehr T. Moj D, et al. Among authors: lehr t. Cancer Chemother Pharmacol. 2017 Nov;80(5):1013-1026. doi: 10.1007/s00280-017-3447-x. Epub 2017 Oct 7. Cancer Chemother Pharmacol. 2017. PMID: 28988277 Free PMC article.

9

A physiologically based pharmacokinetic (PBPK) parent-metabolite model of the chemotherapeutic zoptarelin doxorubicin-integration of in vitro results, Phase I and Phase II data and model application for drug-drug interaction potential analysis.

Hanke N, Teifel M, Moj D, Wojtyniak JG, Britz H, Aicher B, Sindermann H, Ammer N, Lehr T. Hanke N, et al. Among authors: lehr t. Cancer Chemother Pharmacol. 2018 Feb;81(2):291-304. doi: 10.1007/s00280-017-3495-2. Epub 2017 Dec 4. Cancer Chemother Pharmacol. 2018. PMID: 29204687 Clinical Trial.

10

How to disentangle psychobiological stress reactivity and recovery: A comparison of model-based and non-compartmental analyses of cortisol concentrations.

Miller R, Wojtyniak JG, Weckesser LJ, Alexander NC, Engert V, Lehr T. Miller R, et al. Among authors: lehr t. Psychoneuroendocrinology. 2018 Apr;90:194-210. doi: 10.1016/j.psyneuen.2017.12.019. Epub 2017 Dec 29. Psychoneuroendocrinology. 2018. PMID: 29370954

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