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Therapeutic efficacy of artesunate-amodiaquine and artemether-lumefantrine and polymorphism in Plasmodium falciparum kelch13-propeller gene in Equatorial Guinea.
Riloha Rivas M, Warsame M, Mbá Andeme R, Nsue Esidang S, Ncogo PR, Phiri WP, Oki Eburi C, Edú Maye CE, Menard D, Legrand E, Berzosa P, Garcia L, Lao Seoane AK, Ntabangana SC, Ringwald P. Riloha Rivas M, et al. Among authors: legrand e. Malar J. 2021 Jun 22;20(1):275. doi: 10.1186/s12936-021-03807-x. Malar J. 2021. PMID: 34158055 Free PMC article.
Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda.
Uwimana A, Legrand E, Stokes BH, Ndikumana JM, Warsame M, Umulisa N, Ngamije D, Munyaneza T, Mazarati JB, Munguti K, Campagne P, Criscuolo A, Ariey F, Murindahabi M, Ringwald P, Fidock DA, Mbituyumuremyi A, Menard D. Uwimana A, et al. Among authors: legrand e. Nat Med. 2020 Oct;26(10):1602-1608. doi: 10.1038/s41591-020-1005-2. Epub 2020 Aug 3. Nat Med. 2020. PMID: 32747827 Free PMC article.
African isolates show a high proportion of multiple copies of the Plasmodium falciparum plasmepsin-2 gene, a piperaquine resistance marker.
Leroy D, Macintyre F, Adoke Y, Ouoba S, Barry A, Mombo-Ngoma G, Ndong Ngomo JM, Varo R, Dossou Y, Tshefu AK, Duong TT, Phuc BQ, Laurijssens B, Klopper R, Khim N, Legrand E, Ménard D. Leroy D, et al. Among authors: legrand e. Malar J. 2019 Apr 10;18(1):126. doi: 10.1186/s12936-019-2756-4. Malar J. 2019. PMID: 30967148 Free PMC article. Clinical Trial.
Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness.
Stokes BH, Dhingra SK, Rubiano K, Mok S, Straimer J, Gnädig NF, Deni I, Schindler KA, Bath JR, Ward KE, Striepen J, Yeo T, Ross LS, Legrand E, Ariey F, Cunningham CH, Souleymane IM, Gansané A, Nzoumbou-Boko R, Ndayikunda C, Kabanywanyi AM, Uwimana A, Smith SJ, Kolley O, Ndounga M, Warsame M, Leang R, Nosten F, Anderson TJ, Rosenthal PJ, Ménard D, Fidock DA. Stokes BH, et al. Among authors: legrand e. Elife. 2021 Jul 19;10:e66277. doi: 10.7554/eLife.66277. Elife. 2021. PMID: 34279219 Free PMC article.
Author Correction: Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda.
Uwimana A, Legrand E, Stokes BH, Ndikumana JM, Warsame M, Umulisa N, Ngamije D, Munyaneza T, Mazarati JB, Munguti K, Campagne P, Criscuolo A, Ariey F, Murindahabi M, Ringwald P, Fidock DA, Mbituyumuremyi A, Menard D. Uwimana A, et al. Among authors: legrand e. Nat Med. 2021 Jun;27(6):1113-1115. doi: 10.1038/s41591-021-01365-y. Nat Med. 2021. PMID: 34045739 Free PMC article. No abstract available.
A novel field-based molecular assay to detect validated artemisinin-resistant k13 mutants.
Vachot-Ganée L, Khim N, Iannello A, Legrand E, Kim S, Eam R, Khean C, Ken M, Ashley E, Tun KM, Dhorda M, Nosten F, Souleymane IM, Blein S, Pachot A, Ariey F, Kaiser K, Ménard D. Vachot-Ganée L, et al. Among authors: legrand e. Malar J. 2018 Apr 24;17(1):175. doi: 10.1186/s12936-018-2329-y. Malar J. 2018. PMID: 29690890 Free PMC article.
377 results