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Initial Pharmacological Characterization of a Major Hydroxy Metabolite of PF-5190457: Inverse Agonist Activity of PF-6870961 at the Ghrelin Receptor.
Deschaine SL, Hedegaard MA, Pince CL, Farokhnia M, Moose JE, Stock IA, Adusumalli S, Akhlaghi F, Hougland JL, Sulima A, Rice KC, Koob GF, Vendruscolo LF, Holst B, Leggio L. Deschaine SL, et al. Among authors: leggio l. J Pharmacol Exp Ther. 2023 Aug;386(2):117-128. doi: 10.1124/jpet.122.001393. Epub 2023 Jan 11. J Pharmacol Exp Ther. 2023. PMID: 36631279 Free PMC article.
Genetic or pharmacological GHSR blockade has sexually dimorphic effects in rodents on a high-fat diet.
Leggio L, Leko A, Gregory-Flores A, Marchette R, Gomez J, Vendruscolo J, Repunte-Canonigo V, Chuong V, Deschaine S, Whiting K, Jackson S, Cornejo M, Perello M, You ZB, Eckhaus M, Janda K, Zorman B, Sumazin P, Koob G, Michaelides M, Sanna PP, Vendruscolo L. Leggio L, et al. Res Sq [Preprint]. 2023 Oct 18:rs.3.rs-3236045. doi: 10.21203/rs.3.rs-3236045/v1. Res Sq. 2023. PMID: 37886546 Free PMC article. Preprint.
Role of ghrelin hormone in the development of alcohol-associated liver disease.
Mahalingam S, Bellamkonda R, Kharbanda KK, Arumugam MK, Kumar V, Casey CA, Leggio L, Rasineni K. Mahalingam S, et al. Among authors: leggio l. Biomed Pharmacother. 2024 May;174:116595. doi: 10.1016/j.biopha.2024.116595. Epub 2024 Apr 19. Biomed Pharmacother. 2024. PMID: 38640709 Free article.
A randomized controlled experimental medicine study of ghrelin in value-based decision making.
Pietrzak M, Yngve A, Hamilton JP, Kämpe R, Boehme R, Asratian A, Gauffin E, Löfberg A, Gustavson S, Persson E, Capusan AJ, Leggio L, Perini I, Tinghög G, Heilig M. Pietrzak M, et al. Among authors: leggio l. J Clin Invest. 2023 Jun 15;133(12):e168260. doi: 10.1172/JCI168260. J Clin Invest. 2023. PMID: 37040196 Free PMC article. Clinical Trial.
447 results