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Concurrent BMP Signaling Maintenance and TGF-β Signaling Inhibition Is a Hallmark of Natural Resistance to Muscle Atrophy in the Hibernating Bear.
Cussonneau L, Boyer C, Brun C, Deval C, Loizon E, Meugnier E, Gueret E, Dubois E, Taillandier D, Polge C, Béchet D, Gauquelin-Koch G, Evans AL, Arnemo JM, Swenson JE, Blanc S, Simon C, Lefai E, Bertile F, Combaret L. Cussonneau L, et al. Among authors: lefai e. Cells. 2021 Jul 23;10(8):1873. doi: 10.3390/cells10081873. Cells. 2021. PMID: 34440643 Free PMC article.
The microRNA signature in response to insulin reveals its implication in the transcriptional action of insulin in human skeletal muscle and the role of a sterol regulatory element-binding protein-1c/myocyte enhancer factor 2C pathway.
Granjon A, Gustin MP, Rieusset J, Lefai E, Meugnier E, Güller I, Cerutti C, Paultre C, Disse E, Rabasa-Lhoret R, Laville M, Vidal H, Rome S. Granjon A, et al. Among authors: lefai e. Diabetes. 2009 Nov;58(11):2555-64. doi: 10.2337/db09-0165. Epub 2009 Aug 31. Diabetes. 2009. PMID: 19720801 Free PMC article.
FTO is increased in muscle during type 2 diabetes, and its overexpression in myotubes alters insulin signaling, enhances lipogenesis and ROS production, and induces mitochondrial dysfunction.
Bravard A, Lefai E, Meugnier E, Pesenti S, Disse E, Vouillarmet J, Peretti N, Rabasa-Lhoret R, Laville M, Vidal H, Rieusset J. Bravard A, et al. Among authors: lefai e. Diabetes. 2011 Jan;60(1):258-68. doi: 10.2337/db10-0281. Epub 2010 Oct 13. Diabetes. 2011. PMID: 20943749 Free PMC article.
Sirtuin 1 regulates SREBP-1c expression in a LXR-dependent manner in skeletal muscle.
Defour A, Dessalle K, Castro Perez A, Poyot T, Castells J, Gallot YS, Durand C, Euthine V, Gu Y, Béchet D, Peinnequin A, Lefai E, Freyssenet D. Defour A, et al. Among authors: lefai e. PLoS One. 2012;7(9):e43490. doi: 10.1371/journal.pone.0043490. Epub 2012 Sep 11. PLoS One. 2012. PMID: 22984430 Free PMC article.
A socio-ecological approach promoting physical activity and limiting sedentary behavior in adolescence showed weight benefits maintained 2.5 years after intervention cessation.
Simon C, Kellou N, Dugas J, Platat C, Copin N, Schweitzer B, Hausser F, Bergouignan A, Lefai E, Blanc S. Simon C, et al. Among authors: lefai e. Int J Obes (Lond). 2014 Jul;38(7):936-43. doi: 10.1038/ijo.2014.23. Epub 2014 Feb 10. Int J Obes (Lond). 2014. PMID: 24509504 Free PMC article. Clinical Trial.
79 results