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Page 1
Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer.
Malla SB, Byrne RM, Lafarge MW, Corry SM, Fisher NC, Tsantoulis PK, Mills ML, Ridgway RA, Lannagan TRM, Najumudeen AK, Gilroy KL, Amirkhah R, Maguire SL, Mulholland EJ, Belnoue-Davis HL, Grassi E, Viviani M, Rogan E, Redmond KL, Sakhnevych S, McCooey AJ, Bull C, Hoey E, Sinevici N, Hall H, Ahmaderaghi B, Domingo E, Blake A, Richman SD, Isella C, Miller C, Bertotti A, Trusolino L, Loughrey MB, Kerr EM, Tejpar S, Maughan TS, Lawler M, Campbell AD, Leedham SJ, Koelzer VH, Sansom OJ, Dunne PD. Malla SB, et al. Among authors: leedham sj. Nat Genet. 2024 Mar;56(3):458-472. doi: 10.1038/s41588-024-01654-5. Epub 2024 Feb 13. Nat Genet. 2024. PMID: 38351382 Free PMC article.
Advances in colon cancer research: in vitro and animal models.
Lannagan TR, Jackstadt R, Leedham SJ, Sansom OJ. Lannagan TR, et al. Among authors: leedham sj. Curr Opin Genet Dev. 2021 Feb;66:50-56. doi: 10.1016/j.gde.2020.12.003. Epub 2021 Jan 7. Curr Opin Genet Dev. 2021. PMID: 33422950 Free PMC article. Review.
Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis.
Leach JDG, Vlahov N, Tsantoulis P, Ridgway RA, Flanagan DJ, Gilroy K, Sphyris N, Vázquez EG, Vincent DF, Faller WJ, Hodder MC, Raven A, Fey S, Najumudeen AK, Strathdee D, Nixon C, Hughes M, Clark W, Shaw R; S:CORT consortium; van Hooff SR, Huels DJ, Medema JP, Barry ST, Frame MC, Unciti-Broceta A, Leedham SJ, Inman GJ, Jackstadt R, Thompson BJ, Campbell AD, Tejpar S, Sansom OJ. Leach JDG, et al. Among authors: leedham sj. Nat Commun. 2021 Jun 8;12(1):3464. doi: 10.1038/s41467-021-23717-5. Nat Commun. 2021. PMID: 34103493 Free PMC article.
Molecular Subtyping Resource: a user-friendly tool for rapid biological discovery from transcriptional data.
Ahmaderaghi B, Amirkhah R, Jackson J, Lannagan TRM, Gilroy K, Malla SB, Redmond KL, Quinn G, McDade SS, ACRCelerate Consortium, Maughan T, Leedham S, Campbell ASD, Sansom OJ, Lawler M, Dunne PD. Ahmaderaghi B, et al. Dis Model Mech. 2022 Mar 1;15(3):dmm049257. doi: 10.1242/dmm.049257. Epub 2022 Mar 30. Dis Model Mech. 2022. PMID: 35112706 Free PMC article.
Activation of innate-adaptive immune machinery by poly(I:C) exposes a therapeutic vulnerability to prevent relapse in stroma-rich colon cancer.
Corry SM, McCorry AM, Lannagan TR, Leonard NA, Fisher NC, Byrne RM, Tsantoulis P, Cortes-Lavaud X, Amirkhah R, Redmond KL, McCooey AJ, Malla SB, Rogan E, Sakhnevych S, Gillespie MA, White M, Richman SD, Jackstadt RF, Campbell AD, Maguire S; S:CORT and ACRCelerate consortia; McDade SS, Longley DB, Loughrey MB, Coleman HG, Kerr EM, Tejpar S, Maughan T, Leedham SJ, Small DM, Ryan AE, Sansom OJ, Lawler M, Dunne PD. Corry SM, et al. Among authors: leedham sj. Gut. 2022 Dec;71(12):2502-2517. doi: 10.1136/gutjnl-2021-326183. Epub 2022 Apr 27. Gut. 2022. PMID: 35477539 Free PMC article.
Biological Misinterpretation of Transcriptional Signatures in Tumor Samples Can Unknowingly Undermine Mechanistic Understanding and Faithful Alignment with Preclinical Data.
Fisher NC, Byrne RM, Leslie H, Wood C, Legrini A, Cameron AJ, Ahmaderaghi B, Corry SM, Malla SB, Amirkhah R, McCooey AJ, Rogan E, Redmond KL, Sakhnevych S, Domingo E, Jackson J, Loughrey MB, Leedham S, Maughan T, Lawler M, Sansom OJ, Lamrock F, Koelzer VH, Jamieson NB, Dunne PD. Fisher NC, et al. Clin Cancer Res. 2022 Sep 15;28(18):4056-4069. doi: 10.1158/1078-0432.CCR-22-1102. Clin Cancer Res. 2022. PMID: 35792866 Free PMC article.
Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia.
Vasquez EG, Nasreddin N, Valbuena GN, Mulholland EJ, Belnoue-Davis HL, Eggington HR, Schenck RO, Wouters VM, Wirapati P, Gilroy K, Lannagan TRM, Flanagan DJ, Najumudeen AK, Omwenga S, McCorry AMB, Easton A, Koelzer VH, East JE, Morton D, Trusolino L, Maughan T, Campbell AD, Loughrey MB, Dunne PD, Tsantoulis P, Huels DJ, Tejpar S, Sansom OJ, Leedham SJ. Vasquez EG, et al. Among authors: leedham sj. Cell Stem Cell. 2022 Aug 4;29(8):1213-1228.e8. doi: 10.1016/j.stem.2022.07.008. Cell Stem Cell. 2022. PMID: 35931031 Free PMC article.
Exploiting differential Wnt target gene expression to generate a molecular biomarker for colorectal cancer stratification.
Kleeman SO, Koelzer VH, Jones HJ, Vazquez EG, Davis H, East JE, Arnold R, Koppens MA, Blake A, Domingo E, Cunningham C, Beggs AD, Pestinger V, Loughrey MB, Wang LM, Lannagan TR, Woods SL, Worthley D, Consortium SC, Tomlinson I, Dunne PD, Maughan T, Leedham SJ. Kleeman SO, et al. Among authors: leedham sj. Gut. 2020 Jun;69(6):1092-1103. doi: 10.1136/gutjnl-2019-319126. Epub 2019 Sep 28. Gut. 2020. PMID: 31563876 Free PMC article.
Image-based consensus molecular subtype (imCMS) classification of colorectal cancer using deep learning.
Sirinukunwattana K, Domingo E, Richman SD, Redmond KL, Blake A, Verrill C, Leedham SJ, Chatzipli A, Hardy C, Whalley CM, Wu CH, Beggs AD, McDermott U, Dunne PD, Meade A, Walker SM, Murray GI, Samuel L, Seymour M, Tomlinson I, Quirke P, Maughan T, Rittscher J, Koelzer VH; S:CORT consortium. Sirinukunwattana K, et al. Among authors: leedham sj. Gut. 2021 Mar;70(3):544-554. doi: 10.1136/gutjnl-2019-319866. Epub 2020 Jul 20. Gut. 2021. PMID: 32690604 Free PMC article.
NOTUM from Apc-mutant cells biases clonal competition to initiate cancer.
Flanagan DJ, Pentinmikko N, Luopajärvi K, Willis NJ, Gilroy K, Raven AP, Mcgarry L, Englund JI, Webb AT, Scharaw S, Nasreddin N, Hodder MC, Ridgway RA, Minnee E, Sphyris N, Gilchrist E, Najumudeen AK, Romagnolo B, Perret C, Williams AC, Clevers H, Nummela P, Lähde M, Alitalo K, Hietakangas V, Hedley A, Clark W, Nixon C, Kirschner K, Jones EY, Ristimäki A, Leedham SJ, Fish PV, Vincent JP, Katajisto P, Sansom OJ. Flanagan DJ, et al. Among authors: leedham sj. Nature. 2021 Jun;594(7863):430-435. doi: 10.1038/s41586-021-03525-z. Epub 2021 Jun 2. Nature. 2021. PMID: 34079124 Free PMC article.
86 results