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Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.
Demenais F, Margaritte-Jeannin P, Barnes KC, Cookson WOC, Altmüller J, Ang W, Barr RG, Beaty TH, Becker AB, Beilby J, Bisgaard H, Bjornsdottir US, Bleecker E, Bønnelykke K, Boomsma DI, Bouzigon E, Brightling CE, Brossard M, Brusselle GG, Burchard E, Burkart KM, Bush A, Chan-Yeung M, Chung KF, Couto Alves A, Curtin JA, Custovic A, Daley D, de Jongste JC, Del-Rio-Navarro BE, Donohue KM, Duijts L, Eng C, Eriksson JG, Farrall M, Fedorova Y, Feenstra B, Ferreira MA; Australian Asthma Genetics Consortium (AAGC) collaborators; Freidin MB, Gajdos Z, Gauderman J, Gehring U, Geller F, Genuneit J, Gharib SA, Gilliland F, Granell R, Graves PE, Gudbjartsson DF, Haahtela T, Heckbert SR, Heederik D, Heinrich J, Heliövaara M, Henderson J, Himes BE, Hirose H, Hirschhorn JN, Hofman A, Holt P, Hottenga J, Hudson TJ, Hui J, Imboden M, Ivanov V, Jaddoe VWV, James A, Janson C, Jarvelin MR, Jarvis D, Jones G, Jonsdottir I, Jousilahti P, Kabesch M, Kähönen M, Kantor DB, Karunas AS, Khusnutdinova E, Koppelman GH, Kozyrskyj AL, Kreiner E, Kubo M, Kumar R, Kumar A, Kuokkanen M, Lahousse L, Laitinen T, Laprise C, Lathrop M, Lau S, Lee YA, Lehtimäki T, Letort S, Levin AM, Li G, Liang L, Loehr LR, Londo… See abstract for full author list ➔ Demenais F, et al. Among authors: lee ya. Nat Genet. 2018 Jan;50(1):42-53. doi: 10.1038/s41588-017-0014-7. Epub 2017 Dec 22. Nat Genet. 2018. PMID: 29273806 Free PMC article.
A major susceptibility locus for atopic dermatitis maps to chromosome 3q21.
Lee YA, Wahn U, Kehrt R, Tarani L, Businco L, Gustafsson D, Andersson F, Oranje AP, Wolkertstorfer A, v Berg A, Hoffmann U, Küster W, Wienker T, Rüschendorf F, Reis A. Lee YA, et al. Nat Genet. 2000 Dec;26(4):470-3. doi: 10.1038/82625. Nat Genet. 2000. PMID: 11101848
Phenotypic and genetic heterogeneity in a genome-wide linkage study of asthma families.
Altmüller J, Seidel C, Lee YA, Loesgen S, Bulle D, Friedrichs F, Jellouschek H, Kelber J, Keller A, Schuster A, Silbermann M, Wahlen W, Wolff P, Schlenvoigt G, Rüschendorf F, Nürnberg P, Wjst M. Altmüller J, et al. Among authors: lee ya. BMC Pulm Med. 2005 Jan 5;5:1. doi: 10.1186/1471-2466-5-1. BMC Pulm Med. 2005. PMID: 15634351 Free PMC article.
Filaggrin loss-of-function mutations predispose to phenotypes involved in the atopic march.
Marenholz I, Nickel R, Rüschendorf F, Schulz F, Esparza-Gordillo J, Kerscher T, Grüber C, Lau S, Worm M, Keil T, Kurek M, Zaluga E, Wahn U, Lee YA. Marenholz I, et al. Among authors: lee ya. J Allergy Clin Immunol. 2006 Oct;118(4):866-71. doi: 10.1016/j.jaci.2006.07.026. Epub 2006 Sep 1. J Allergy Clin Immunol. 2006. PMID: 17030239
A common variant on chromosome 11q13 is associated with atopic dermatitis.
Esparza-Gordillo J, Weidinger S, Fölster-Holst R, Bauerfeind A, Ruschendorf F, Patone G, Rohde K, Marenholz I, Schulz F, Kerscher T, Hubner N, Wahn U, Schreiber S, Franke A, Vogler R, Heath S, Baurecht H, Novak N, Rodriguez E, Illig T, Lee-Kirsch MA, Ciechanowicz A, Kurek M, Piskackova T, Macek M, Lee YA, Ruether A. Esparza-Gordillo J, et al. Among authors: lee ya, lee kirsch ma. Nat Genet. 2009 May;41(5):596-601. doi: 10.1038/ng.347. Epub 2009 Apr 6. Nat Genet. 2009. PMID: 19349984
Genome-wide approaches to the etiology of eczema.
Esparza-Gordillo J, Marenholz I, Lee YA. Esparza-Gordillo J, et al. Among authors: lee ya. Curr Opin Allergy Clin Immunol. 2010 Oct;10(5):418-26. doi: 10.1097/ACI.0b013e32833dc75e. Curr Opin Allergy Clin Immunol. 2010. PMID: 20706116 Review.
699 results