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Region-based analysis of rare genomic variants in whole-genome sequencing datasets reveal two novel Alzheimer's disease-associated genes: DTNB and DLG2.
Prokopenko D, Lee S, Hecker J, Mullin K, Morgan S, Katsumata Y; Alzheimer’s Disease Neuroimaging Initiative (ADNI); Weiner MW, Fardo DW, Laird N, Bertram L, Hide W, Lange C, Tanzi RE. Prokopenko D, et al. Among authors: lee s. Mol Psychiatry. 2022 Apr;27(4):1963-1969. doi: 10.1038/s41380-022-01475-0. Epub 2022 Mar 4. Mol Psychiatry. 2022. PMID: 35246634 Free PMC article.
A novel locus for exertional dyspnoea in childhood asthma.
Lee S, Lasky-Su JA, Lange C, Kim W, Kumar PL, McDonald MN, Vaz Fragoso CA, Laurie C, Raby BA, Celedón JC, Cho MH, Won S, Weiss ST, Hecker J; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium. Lee S, et al. Eur Respir J. 2021 Feb 4;57(2):2001224. doi: 10.1183/13993003.01224-2020. Print 2021 Feb. Eur Respir J. 2021. PMID: 32855217 Free PMC article.
An interaction of the 17q12-21 locus with mold exposure in childhood asthma.
Lee S, Lasky-Su J, Kim W, Won S, Laurie C, Celedón JC, Lange C, Weiss ST, Hecker J. Lee S, et al. Pediatr Allergy Immunol. 2021 Feb;32(2):373-376. doi: 10.1111/pai.13376. Epub 2020 Oct 13. Pediatr Allergy Immunol. 2021. PMID: 32946604 Free PMC article. No abstract available.
Novel recessive locus for body mass index in childhood asthma.
Lee S, Lasky-Su J, Won S, Laurie C, Celedón JC, Lange C, Weiss S, Hecker J. Lee S, et al. Thorax. 2021 Dec;76(12):1227-1230. doi: 10.1136/thoraxjnl-2020-215742. Epub 2021 Apr 22. Thorax. 2021. PMID: 33888571 Free PMC article.
Genome-wide association analysis of COVID-19 mortality risk in SARS-CoV-2 genomes identifies mutation in the SARS-CoV-2 spike protein that colocalizes with P.1 of the Brazilian strain.
Hahn G, Wu CM, Lee S, Lutz SM, Khurana S, Baden LR, Haneuse S, Qiao D, Hecker J, DeMeo DL, Tanzi RE, Choudhary MC, Etemad B, Mohammadi A, Esmaeilzadeh E, Cho MH, Li JZ, Randolph AG, Laird NM, Weiss ST, Silverman EK, Ribbeck K, Lange C. Hahn G, et al. Among authors: lee s. Genet Epidemiol. 2021 Oct;45(7):685-693. doi: 10.1002/gepi.22421. Epub 2021 Jun 22. Genet Epidemiol. 2021. PMID: 34159627 Free PMC article.
A missense variant in SHARPIN mediates Alzheimer's disease-specific brain damages.
Park JY, Lee D, Lee JJ, Gim J, Gunasekaran TI, Choi KY, Kang S, Do AR, Jo J, Park J, Park K, Li D, Lee S, Kim H, Dhanasingh I, Ghosh S, Keum S, Choi JH, Song GJ, Sael L, Rhee S, Lovestone S, Kim E, Moon SH, Kim BC, Kim S, Saykin AJ, Nho K, Lee SH, Farrer LA, Jun GR, Won S, Lee KH; Alzheimer’s Disease Neuroimaging Initiative. Park JY, et al. Among authors: lee sh, lee d, lee kh, lee jj, lee s. Transl Psychiatry. 2021 Nov 16;11(1):590. doi: 10.1038/s41398-021-01680-5. Transl Psychiatry. 2021. PMID: 34785643 Free PMC article.
DDX58 Is Associated With Susceptibility to Severe Influenza Virus Infection in Children and Adolescents.
Lee S, Zhang Y, Newhams M, Novak T, Thomas PG, Mourani PM, Hall MW, Loftis LL, Cvijanovich NZ, Tarquinio KM, Schwarz AJ, Weiss SL, Thomas NJ, Markovitz B, Cullimore ML, Sanders RC, Zinter MS, Sullivan JE, Halasa NB, Bembea MM, Giuliano JS, Typpo KV, Nofziger RA, Shein SL, Kong M, Coates BM, Weiss ST, Lange C, Su HC, Randolph AG; Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Pediatric Intensive Care Influenza (PICFlu) Investigators and the Trans-Omics for Precision Medicine (TOPMed) Investigators. Lee S, et al. J Infect Dis. 2022 Nov 28;226(11):2030-2036. doi: 10.1093/infdis/jiac350. J Infect Dis. 2022. PMID: 35986912 Free PMC article.
FGF20 and PGM2 variants are associated with childhood asthma in family-based whole-genome sequencing studies.
Hecker J, Chun S, Samiei A, Liu C, Laurie C, Kachroo P, Lutz SM, Lee S, Smith AV, Lasky-Su J, Cho MH, Sharma S, Soto Quirós ME, Avila L, Celedón JC, Raby B, Zhou X, Silverman EK, DeMeo DL; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; Lange C, Weiss ST. Hecker J, et al. Among authors: lee s. Hum Mol Genet. 2023 Jan 27;32(4):696-707. doi: 10.1093/hmg/ddac258. Hum Mol Genet. 2023. PMID: 36255742 Free PMC article.
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